singleCellHaystack: Finding Needles (=differentially Expressed Genes) in Haystacks (=single Cell Data)

Identification of differentially expressed genes (DEGs) is a key step in single-cell transcriptomics data analysis. 'singleCellHaystack' predicts DEGs without relying on clustering of cells into arbitrary clusters. Single-cell RNA-seq (scRNA-seq) data is often processed to fewer dimensions using Principal Component Analysis (PCA) and represented in 2-dimensional plots (e.g. t-SNE or UMAP plots). 'singleCellHaystack' uses Kullback-Leibler divergence to find genes that are expressed in subsets of cells that are non-randomly positioned in a these multi-dimensional spaces or 2D representations. For the theoretical background of 'singleCellHaystack' we refer to Vandenbon and Diez (Nature Communications, 2020) <doi:10.1038/s41467-020-17900-3>.

Package details

AuthorAlexis Vandenbon [aut, cre] (<>), Diego Diez [aut] (<>)
MaintainerAlexis Vandenbon <>
LicenseMIT + file LICENSE
Package repositoryView on CRAN
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singleCellHaystack documentation built on March 28, 2021, 9:12 a.m.