system_set_guess: Alter Initial Guess and Parameter Bounds

In ubiquity: PKPD, PBPK, and Systems Pharmacology Modeling Tools

Alter Initial Guess and Parameter Bounds

Description

Default values for parameters are taken from the system.txt file either when the parameter was defined (<P>) or when it was reassigned for a parameter set (<PSET:?:?>?). These can be altered at the scripting level using this function.

Usage

system_set_guess(cfg, pname, value, lb = NULL, ub = NULL)

Arguments

cfg	ubiquity system object
pname	name of parameter to set
value	value to assign
lb	optionally change the lower bound (NULL)
ub	optionally change the upper bound (NULL)

Details

When performing a parameter estimation, the initial guess will be the value specified in the system.txt file for the currently selected parameter set. The following command can be used after the parameter set has been selected to specify the value (VALUE) of the parameter PNAME and optionally the lower (lb) and upper (ub) bounds:

cfg = system_set_guess(cfg, pname="PNAME", value=VALUE, lb=NULL, ub=NULL)

To set the initial guess for the parameter Vc to a value of 3, the following would be used:

cfg = system_set_guess(cfg, "Vc", value=3)

To specify the guess and overwrite the upper bound on Vc and set it to 5

cfg = system_set_guess(cfg, "Vc", value=3, ub=5) 

Value

cfg ubiquity system object with guess and bounds assigned

ubiquity documentation built on May 29, 2024, 12:02 p.m.