scoreCurve: CSS facilitate function - scoreCurve for curves fitted by...

In DrugComb/TidyComb: Preparing drug combination data for DrugComb

CSS facilitate function - scoreCurve for curves fitted by LL.4

Description

New function used to score sensitivities given either a single-agent or a fixed conc (combination) columns. The function calculates the AUC of the log10-scaled dose-response curve. IMPORTANT: note that with LL.4() calls, this value is already logged since the input concentrations are logged.

Usage

scoreCurve(b, c, d, m, c1, c2, t)

Arguments

b	numeric, fitted parameter b from LL.4() model
c	numeric, fitted parameter c from LL.4() model
d	numeric, fitted parameter d from LL.4() model
m	numeric, relative IC50 for the curve. log10(e), where e is the fitted parameter e from LL.4() model
c1	numeric, log10(min conc) (this is the minimal nonzero concentration)
c2	numeric, log10(max conc) (this is the maximal concentration)
t	numeric, threshold (usually set to zero)

Value

numeric, RI or CSS scores

Author(s)

Jing Tang [e-mail] Shuyu Zheng [e-mail]

DrugComb/TidyComb documentation built on June 22, 2022, 2:49 a.m.