readGistic: Read and summarize gistic output.

In PoisonAlien/maftools: Summarize, Analyze and Visualize MAF Files

Read and summarize gistic output.

Description

A little function to summarize gistic output files. Summarized output is returned as a list of tables.

Usage

readGistic(
  gisticDir = NULL,
  gisticAllLesionsFile = NULL,
  gisticAmpGenesFile = NULL,
  gisticDelGenesFile = NULL,
  gisticScoresFile = NULL,
  cnLevel = "all",
  isTCGA = FALSE,
  verbose = TRUE
)

Arguments

gisticDir	Directory containing GISTIC results. Default NULL. If provided all relevent files will be imported. Alternatively, below arguments can be used to import required files.
gisticAllLesionsFile	All Lesions file generated by gistic. e.g; all_lesions.conf_XX.txt, where XX is the confidence level. Required. Default NULL.
gisticAmpGenesFile	Amplification Genes file generated by gistic. e.g; amp_genes.conf_XX.txt, where XX is the confidence level. Default NULL.
gisticDelGenesFile	Deletion Genes file generated by gistic. e.g; del_genes.conf_XX.txt, where XX is the confidence level. Default NULL.
gisticScoresFile	scores.gistic file generated by gistic.
cnLevel	level of CN changes to use. Can be 'all', 'deep' or 'shallow'. Default uses all i.e, genes with both 'shallow' or 'deep' CN changes
isTCGA	Is the data from TCGA. Default FALSE.
verbose	Default TRUE

Details

Requires output files generated from GISTIC. Gistic documentation can be found here ftp://ftp.broadinstitute.org/pub/GISTIC2.0/GISTICDocumentation_standalone.htm

Value

A list of summarized data.

Examples

all.lesions <- system.file("extdata", "all_lesions.conf_99.txt", package = "maftools")
amp.genes <- system.file("extdata", "amp_genes.conf_99.txt", package = "maftools")
del.genes <- system.file("extdata", "del_genes.conf_99.txt", package = "maftools")
scores.gistic <- system.file("extdata", "scores.gistic", package = "maftools")
laml.gistic = readGistic(gisticAllLesionsFile = all.lesions, gisticAmpGenesFile = amp.genes, gisticDelGenesFile = del.genes, gisticScoresFile = scores.gistic, isTCGA = TRUE)

PoisonAlien/maftools documentation built on April 7, 2024, 2:49 a.m.