RussBainer/gCrisprTools: Suite of Functions for Pooled Crispr Screen QC and Analysis

Set of tools for evaluating pooled high-throughput screening experiments, typically employing CRISPR/Cas9 or shRNA expression cassettes. Contains methods for interrogating library and cassette behavior within an experiment, identifying differentially abundant cassettes, aggregating signals to identify candidate targets for empirical validation, hypothesis testing, and comprehensive reporting. Version 2.0 extends these applications to include a variety of tools for contextualizing and integrating signals across many experiments, incorporates extended signal enrichment methodologies via the "sparrow" package, and streamlines many formal requirements to aid in interpretablity.

Getting started

Package details

AuthorRussell Bainer, Dariusz Ratman, Steve Lianoglou, Peter Haverty
Bioconductor views BiomedicalInformatics CRISPR CellBiology DifferentialExpression ExperimentalDesign FunctionalGenomics GeneSetEnrichment Genetics ImmunoOncology MultipleComparison Normalization Pharmacogenetics Pharmacogenomics PooledScreens Preprocessing QualityControl RNASeq Regression Software SystemsBiology Visualization
MaintainerRussell Bainer <>
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
RussBainer/gCrisprTools documentation built on Nov. 5, 2022, 2:35 p.m.