library(shiny)
library(shinyBS)
library(shinydashboard)
library(shinyWidgets)
library(V8)
library(ggplot2)
library(shinyjs)
library(magrittr)
shinyServer(function(input, output, session) {
shinyjs::useShinyjs()
# define the model name once here. It will be used throughout this server file
# this will make it easier to create new model UI/SERVERS
model <- "fishPBPK"
dataset <- reactiveValues()
dataset$savedat <- reactiveVal(c("No","none"))
dataset$iviveDat <- reactiveVal(c("No",0,0,0))
parameterSets <- reactiveValues()
parameterSets$savedat <- reactiveVal(c("No","",0))
parameterSets$sverestdat <- reactiveVal(c("None",0))
parameterSets$importdat <- reactiveVal(c("No","",0))
parameterSets$importSeem <- reactiveVal(c("No"))
parameterSets$importSheds <- reactiveVal(c("No"))
parameterSets$importBatch <- reactiveVal(c("No"))
parameterSets$importAllData <- reactiveVal(c("No"))
parameterSets$sim_table <- data.frame("Col1"="","Col2"=0,"Col3"=0,row.names = NULL)
parameterSets$vardat <- reactiveVal(c("None","",0))
expo_set <- getAllSetChoices("expo")
physio_set <- getAllSetChoices("physio")
chem_set <- getAllSetChoices("chem")
sim_set <- getAllSetChoices("sim")
physiovar <-getVariabilitySetChoices("physio")
chemvar <-getVariabilitySetChoices("chem")
expovar <-getVariabilitySetChoices("expo")
parameterSets$expo <- reactiveVal(expo_set)
parameterSets$physio <- reactiveVal(physio_set)
parameterSets$chem <- reactiveVal(chem_set)
parameterSets$sim <- reactiveVal(sim_set)
parameterSets$physiovar <- reactiveVal(physiovar)
parameterSets$chemvar <- reactiveVal(chemvar)
parameterSets$expovar <- reactiveVal(expovar)
observe({
# print("## 1 ##")
exposet <- parameterSets$expo()
updateSelectizeInput(session,"sel_set_expo",choices = exposet)
physioset <- parameterSets$physio()
updateSelectizeInput(session,"sel_set_physio",choices = physioset)
chemset <- parameterSets$chem()
updateSelectizeInput(session,"sel_set_chem",choices = chemset)
physiovar <- parameterSets$physiovar()
physiovar <- c("None"="0",physiovar)
updateSelectizeInput(session,"sel_set_physiovar",choices = physiovar)
chemvar <- parameterSets$chemvar()
chemvar <- c("None"="0",chemvar)
updateSelectizeInput(session,"sel_set_chemvar",choices = chemvar)
expovar <- parameterSets$expovar()
expovar <- c("None"="0",expovar)
updateSelectizeInput(session,"sel_set_expovar",choices = expovar)
})
# get global variables needed to run the model
# get the parameter table for physiological and exposure variables.
query <- sprintf("SELECT Name,Var,Units,ParamType,Variability FROM ParamNames Where Model='%s' AND ParamSet = 'Physiological' AND UIParams = 'TRUE';",
model)
physio_name_df <- mainDbSelect(query)
query <- sprintf("SELECT Name,Var,Units,ParamType,Variability FROM ParamNames Where Model='%s' AND ParamSet = 'Exposure' AND UIParams = 'TRUE';",
model)
expo_name_df <- mainDbSelect(query)
query <- sprintf("SELECT Name,Var,Units,ParamType,Variability FROM ParamNames Where Model='%s' AND ParamSet = 'Chemical'AND UIParams = 'TRUE' ;",
model)
chem_name_df <- mainDbSelect(query)
#### Update the parameter set dropdowns if they exist for physiological and exposure sets
set_choices <- getAllSetChoices(set_type = "physio")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_physio",choices = set_choices)
shinyBS::updateButton(session,"btn_use_lifecourse",style = "primary")
shinyBS::updateButton(session,"btn_useQSAR4Partition",style = "primary")
}
set_choices <- getAllSetChoices(set_type = "expo")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_expo",choices = set_choices)
}
set_choices <- getAllSetChoices(set_type = "chem")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_chem",choices = set_choices)
updateSelectizeInput(session,"sel_chem4Partition",choices = set_choices)
}
set_choices <- getAllSetChoices(set_type = "sim")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_sim",choices = set_choices)
}
obs_conc_set <- getObservationSetChoices("conc")
if (length(obs_conc_set)>0){
updatePickerInput(session,"cplt_data",
choices = c("No Dataset"="none",obs_conc_set),
selected = "none")
}
set_choices<- getVariabilitySetChoices("physio")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_physio_var",
choices = set_choices)
}
set_choices<- getVariabilitySetChoices("chem")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_chem_var",
choices = set_choices)
}
set_choices<- getVariabilitySetChoices("expo")
if (length(set_choices)>0){
updateSelectizeInput(session,"sel_expo_var",
choices = set_choices)
}
compartment_list <-c("fat","liver","kidney","rpf","spf")
vol_ids <- c("fat"="ms_vfatc",
"liver"="ms_vlivc","kidney"="ms_vkdnc",
"rpf"="ms_vrpfc","spf"="ms_vspfc",
"bw"="ms_bw")
flow_ids <- c("fat"="ms_qfatc","liver"="ms_qlivc",
"kidney"="ms_qkdnc",
"rpf"="ms_qrpfc","spf"="ms_qspfc")
########### The next code chunk deals with updating select inputs for all parameter sets]
# Import SEEM, SHEDS-HT, batch exposure, and TRA data
observeEvent(input$btn_import_expo,{
# print("## 2 ##")
importAllExposureDataUI(paste0("allData",input$btn_import_expo))
parameterSets$importAllData <- callModule(importAllExposureData,
paste0("allData",input$btn_import_expo),
expo_name_df)
})
observe({
# print("## 3 ##")
result_vector <- parameterSets$importAllData
if(result_vector()[1]=="Yes"){
set_type <- "expo"
set_list <- getAllSetChoices(set_type)
parameterSets[[set_type]] <- reactiveVal(set_list)
updateSelectizeInput(session,paste0("sel_",set_type),
choices = set_list)
}
})
### Import button current for chemicals only
# Import a new chemical set from user or main database
#### Chunk for handling chemical tab
observeEvent(input$btn_import_chem,{
# print("## 4 ##")
importParameterSetUI(paste0("chem",input$btn_import_chem),"chem")
parameterSets$importdat <- callModule(importParameterSet,paste0("chem",input$btn_import_chem),"chem")
})
#### Chunk for handling physiological tab
observeEvent(input$btn_import_physio,{
# print("## 5 ##")
importParameterSetUI(input$btn_import_physio,"physio")
parameterSets$importdat <- callModule(importParameterSet,input$btn_import_physio,"physio")
})
# update the paramter set dropdown if it is changed
observe({
# print("## 6 ##")
result_vector <- parameterSets$importdat
if(result_vector()[1]=="Yes"){
set_type <- result_vector()[2]
set_id <- result_vector()[3]
set_list <- getAllSetChoices(set_type)
parameterSets[[set_type]] <- reactiveVal(set_list)
updateSelectizeInput(session,paste0("sel_",set_type),choices = set_list, selected = set_id)
# updateSelectizeInput(session,paste0("sel_scene_",set_type),choices = set_list)
}
})
#Save a new physiological parameter set
observeEvent(input$btn_saveas_physio,{
# print("## 7 ##")
active_comp <- input$ms_cmplist
compartment_list <-c("fat","liver","kidney","rpf","spf")
inactive_comp <- setdiff(compartment_list,active_comp)
vol_comps <- compartment_list
perfc <- 1
total_vol <- sum(unlist(lapply(vol_comps,function(x){input[[vol_ids[x]]]})))
if(abs(total_vol-perfc)>0.03){
error_text <- sprintf("The total volume of all compartments does not add up to %i %%",
as.integer(perfc*100))
shinyWidgets::sendSweetAlert(session,
title = "Invalid Compartment Configuration",
text = error_text,
type = "error")
}else{
ns <- paste0("physio",input$btn_saveas_physio)
saveAsParameterSetUI(ns,"physio")
parameterSets$savedat <- callModule(saveAsParameterSet,
ns,
"physio",isolate(input),
physio_name_df)
}
})
#Save a new exposure parameter set
observeEvent(input$btn_saveas_expo,{
# print("## 8 ##")
ns <- paste0("expo",input$btn_saveas_expo)
saveAsParameterSetUI(ns,"expo")
parameterSets$savedat <- callModule(saveAsParameterSet,
ns,
"expo",isolate(input),
expo_name_df)
})
#Save a new chemical parameter set
observeEvent(input$btn_saveas_chem,{
# print("## 9 ##")
ns <- paste0("chem",input$btn_saveas_chem)
saveAsParameterSetUI(ns,"chem")
parameterSets$savedat <- callModule(saveAsParameterSet,ns,
"chem",isolate(input),
chem_name_df)
})
# update the paramter set dropdown if it is changed
observe({
# print("## 10 ##")
result_vector <- parameterSets$savedat
if(result_vector()[1]=="Yes"){
set_type <- result_vector()[2]
set_id <- result_vector()[3]
set_list <- getAllSetChoices(set_type)
parameterSets[[set_type]] <- reactiveVal(set_list)
updateSelectizeInput(session,paste0("sel_",set_type),choices = set_list, selected = set_id)
parameterSets$savedat <- reactiveVal(c("No","",0))
# updateSelectizeInput(session,paste0("sel_scene_",set_type),choices = set_list)
}
})
#Save/Restore Button function
observeEvent(input$btn_sverest_physio,{
# print("## 11 ##")
physioid <- input$sel_physio
set_values <- getParameterSet("physio",physioid)
UI_values <- reactiveValuesToList(input)[paste0("ms_",physio_name_df$Var)]
names(UI_values) <- gsub("ms_","",names(UI_values))
saveRestoreParameterSetUI(input$btn_sverest_physio)
parameterSets$sverestdat <- callModule(saveRestoreParameterSet,
input$btn_sverest_physio,
UI_values,set_values,
physio_name_df,"physio")
})
#Save/Restore Button function
observeEvent(input$btn_sverest_expo,{
# print("## 12 ##")
expoid <- input$sel_expo
set_values <- getParameterSet("expo",expoid)
UI_values <- reactiveValuesToList(input)[paste0("ms_",expo_name_df$Var)]
names(UI_values) <- gsub("ms_","",names(UI_values))
saveRestoreParameterSetUI(input$btn_sverest_expo)
parameterSets$sverestdat <- callModule(saveRestoreParameterSet,
input$btn_sverest_expo,
UI_values,set_values,
expo_name_df,"expo")
})
#Save/Restore Button function
observeEvent(input$btn_sverest_chem,{
# print("## 13 ##")
chemid <- input$sel_chem
set_values <- getParameterSet("chem",chemid)
#chem_vars <- subset(chem_name_df$Var,!(chem_name_df$Var %in% c("name","cas","descrp")))
UI_values <- reactiveValuesToList(input)[paste0("ms_",chem_name_df$Var)]
names(UI_values) <- gsub("ms_","",names(UI_values))
saveRestoreParameterSetUI(input$btn_sverest_chem)
parameterSets$sverestdat <- callModule(saveRestoreParameterSet,
input$btn_sverest_chem,
UI_values,set_values,
chem_name_df,"chem")
})
observe({
# print("## 14 ##")
result_vector <- parameterSets$sverestdat()
ops_type <- result_vector[1]
if (ops_type == "save"){
type <- result_vector[5]
input_id <- as.integer(isolate(input[[paste0("sel_",type)]]))
id_name <- paste0(type,"id")
if (type == "physio"){
table_name <- "Physiological"
}else if(type == "chem"){
table_name <- "Chemical"
}else{
table_name <- "Exposure"
}
# create a data frame for the mapply below
val_df <- data.frame("var"=result_vector[2],"val"= result_vector[4],stringsAsFactors = FALSE,row.names = NULL)
# create the query
query_list <-mapply(function(var,val,tbl_nme,id_nme,id){
temp <- sprintf("UPDATE %s SET value = %s WHERE %s = %i AND param = '%s';",
tbl_nme,val,id_nme,id,var)
return(temp)
},
val_df$Variable,val_df$Current.Value,table_name,id_name,input_id,SIMPLIFY = T)
lapply(query_list,projectDbUpdate)
}else if (ops_type == "restore"){
type <- result_vector[5]
if (type == "physio"){
name_data <- physio_name_df
}else if(type == "chem"){
name_data <- chem_name_df
}else{
name_data <- expo_name_df
}
var_type <- sapply(result_vector$Variable,function(var){
tempvar <- name_data$ParamType[which(name_data$Var == var, arr.ind = T)]
return(tempvar)})
change_df <- data.frame("Var"=result_vector$Variable,
"Val" = result_vector[["Original Value"]],
"ParamType"=var_type,
row.names = NULL,
stringsAsFactors = F)
updateUIInputs(session,change_df)
}
})
observeEvent(input$btn_new_varphys,{
# print("## 15 ##")
param_names <- physio_name_df$Name[which(physio_name_df$Variability == "TRUE")]
param_vars <- physio_name_df$Var[which(physio_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("vpn_",input$btn_new_varphys)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"physio","new",param_vars)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observeEvent(input$btn_edit_varphys,{
# print("## 16 ##")
param_names <- physio_name_df$Name[which(physio_name_df$Variability == "TRUE")]
param_vars <- physio_name_df$Var[which(physio_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("vpe_",input$btn_edit_varphys)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"physio","edit",
param_vars,input$sel_physio_var)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observeEvent(input$btn_new_varchem,{
# print("## 17 ##")
param_names <- chem_name_df$Name[which(chem_name_df$Variability == "TRUE")]
param_vars <- chem_name_df$Var[which(chem_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("vcn_",input$btn_new_varchem)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"chem","new",param_vars)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observeEvent(input$btn_edit_varchem,{
# print("## 18 ##")
param_names <- chem_name_df$Name[which(chem_name_df$Variability == "TRUE")]
param_vars <- chem_name_df$Var[which(chem_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("vce_",input$btn_edit_varchem)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"chem","edit",
param_vars,input$sel_chem_var)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observeEvent(input$btn_new_varexpo,{
# print("## 19 ##")
param_names <- expo_name_df$Name[which(expo_name_df$Variability == "TRUE")]
param_vars <- expo_name_df$Var[which(expo_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("ven_",input$btn_new_varexpo)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"expo","new",param_vars)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observeEvent(input$btn_edit_varexpo,{
# print("## 20 ##")
param_names <- expo_name_df$Name[which(expo_name_df$Variability == "TRUE")]
param_vars <- expo_name_df$Var[which(expo_name_df$Variability == "TRUE")]
names(param_vars) <- param_names
ns <- paste0("vee_",input$btn_edit_varexpo)
newEditVariabilityUI(ns)
parameterSets$vardat <- callModule(newEditVariability,ns,"expo","edit",
param_vars,input$sel_expo_var)
### Variability Tab
},ignoreInit = T, ignoreNULL = T)
observe({
# print("## 21 ##")
result_vector <- parameterSets$vardat
if (result_vector()[1]=="Yes"){
set_type <- result_vector()[2]
varid <- result_vector()[3]
set_list <- getVariabilitySetChoices(set_type)
parameterSets[[paste0(set_type,"var")]] <- reactiveVal(set_list)
updateSelectizeInput(session,paste0("sel_",set_type,"_var"),choices = NULL)
updateSelectizeInput(session,
paste0("sel_",set_type,"_var"),
choices = set_list,
selected = as.integer(varid))
}
})
observeEvent(input$sel_physio_var,{
# print("## 22 ##")
varid <- input$sel_physio_var
query <- sprintf("Select var_tble from Variability where varid = %d;",as.integer(varid))
var_data <- projectDbSelect(query)
dataset <- unserialize(charToRaw(var_data$var_tble))
dataset <- dataset[,c(-2)]
output$physio_var_tble <- DT::renderDT(DT::datatable(dataset,rownames = "",
colnames = c("Use Bounds" = 5,
"Upper Bound"=6,
"Lower Bound"=7)
)
)
},ignoreInit = TRUE, ignoreNULL = TRUE)
observeEvent(input$sel_chem_var,{
# print("## 23 ##")
varid <- input$sel_chem_var
query <- sprintf("Select var_tble from Variability where varid = %d;",as.integer(varid))
var_data <- projectDbSelect(query)
dataset <- unserialize(charToRaw(var_data$var_tble))
dataset <- dataset[,c(-2)]
output$chem_var_tble <- DT::renderDT(DT::datatable(dataset,rownames = "",
colnames = c("Use Bounds" = 5,
"Upper Bound"=6,
"Lower Bound"=7)
))
},ignoreInit = TRUE, ignoreNULL = TRUE)
observeEvent(input$sel_expo_var,{
# print("## 24 ##")
varid <- input$sel_expo_var
query <- sprintf("Select var_tble from Variability where varid = %d;",as.integer(varid))
var_data <- projectDbSelect(query)
dataset <- unserialize(charToRaw(var_data$var_tble))
dataset <- dataset[,c(-2)]
output$expo_var_tble <- DT::renderDT(DT::datatable(dataset,rownames = "",
colnames = c("Use Bounds" = 5,
"Upper Bound"=6,
"Lower Bound"=7)
))
},ignoreInit = TRUE, ignoreNULL = TRUE)
#update the inputs for the parameter set selected
observeEvent(input$sel_physio,{
# print("## 25 ##")
physioid <- input$sel_physio
#get values for the inputs
physio_values <- getParameterSet("physio",physioid)
# get all numeric values in the physio names dataframe
params_df <- physio_name_df
params_df$Val <- physio_values[physio_name_df$Var]
params_df[params_df$Var == "frspfkdn", "Val"] <- 0.6
updateUIInputs(session,params_df)
shinyBS::updateButton(session,"btn_use_lifecourse",style = "primary")
shinyBS::updateButton(session,"btn_useQSAR4Partition",style = "primary")
},ignoreInit = TRUE, ignoreNULL = TRUE)
observeEvent(input$sel_expo,{
# print("## 26 ##")
expoid <- input$sel_expo
#get the values for inputs
expo_values <- getParameterSet("expo",expoid)
params_df <- expo_name_df
params_df$Val <- expo_values[expo_name_df$Var]
updateUIInputs(session,params_df)
},ignoreInit = TRUE, ignoreNULL = TRUE)
observeEvent(input$sel_chem,{
# print("## 27 ##")
chemid <- input$sel_chem
#get the values for inputs
chem_values <- getParameterSet("chem",chemid)
params_df <- chem_name_df
params_df$Val <- chem_values[chem_name_df$Var]
updateUIInputs(session,params_df)
},ignoreInit = TRUE, ignoreNULL = TRUE)
### CODE CHUNK FOR HANDLING SIMULATIONS TAB
# Save a new simulation
observeEvent(input$save_sim,{
# print("## 28 ##")
if (any(c(input$sim_name,input$sim_descrp)=="")){
sendSweetAlert(session,"Error",
"Need to provide Name and Decription for the simulation",
type = "error")
}else{
simid <- getNextID("SimulationsSet")
sim_name <- input$sim_name
sim_descrp <- input$sim_descrp
sim_start <- input$sim_start
sim_dur <- input$sim_dur
dur_units <- "h"
mc_num <- ifelse(input$mc_mode,input$mc_num,0)
chemid <- as.integer(input$sel_set_chem)
physioid <- as.integer(input$sel_set_physio)
expoid <- as.integer(input$sel_set_expo)
metabid <- 0
physiovarid <- as.integer(input$sel_set_physiovar)
chemvarid <- as.integer(input$sel_set_chemvar)
expovarid <- as.integer(input$sel_set_expovar)
query <- paste(strwrap(sprintf("INSERT INTO SimulationsSet (simid,name,descrp,expoid,physioid,
chemid,metabid,physiovarid,chemvarid,expovarid,tstart,sim_dur,dur_units,mc_num) Values
(%d,'%s','%s',%i,%i,%i,%i,%i,%i,%i,%f,%f,'%s',%i) ;",
simid,sim_name,sim_descrp,
expoid,physioid,
chemid,metabid,
physiovarid,chemvarid,
expovarid,
sim_start,sim_dur,dur_units,mc_num),
simplify = T),
sep = " ",collapse = "")
#print(query)
projectDbUpdate(query)
sim_sets <- getAllSetChoices("sim")
updateSelectizeInput(session,"sel_sim",choices = sim_sets)
updateTextInput(session,"sim_name",value = "")
updateTextAreaInput(session,"sim_descrp",value = "")
sendSweetAlert(session,"Success",
sprintf("Simulation saved as %s",sim_name),
type = "success")
}
})
observeEvent(input$sel_sim,{
# print("## 29 ##")
simid <- as.integer(input$sel_sim)
# get pertinent data from the database
# get All values from the simulations database
query <- sprintf("Select name,descrp,metabid,expoid,physioid,chemid,tstart,sim_dur FROM SimulationsSet Where simid = %i;",
simid)
result <- projectDbSelect(query)
metabid <- as.integer(result[["metabid"]])
chemid <- as.integer(result[["chemid"]])
expoid <- as.integer(result[["expoid"]])
physioid <- as.integer(result[["physioid"]])
sim_name <- result[["name"]]
sim_descrp <- result[["descrp"]]
tstart <- round(result[["tstart"]],2)
sim_dur <- round(result[["sim_dur"]],2)
output$sim_name <- renderText(sim_name)
output$sim_descrp <- renderText(sim_descrp)
output$sim_start <- renderText(as.character(tstart))
output$sim_dur <- renderText(as.character(sim_dur))
# get chemical name from chem table
query <- sprintf("SELECT name from ChemicalSet WHERE chemid = %i ;",
chemid)
result <- projectDbSelect(query)
chem_name <- result$name
output$sim_chem <- renderText(chem_name)
# get exposure name form exposure set table
query <- sprintf("SELECT name from ExposureSet WHERE expoid = %i ;",
expoid)
result <- projectDbSelect(query)
expo_name <- result$name
output$sim_expo <- renderText(expo_name)
#print(output)
# # get metabolism data.
# print(paste0("metabid: ", metabid, ", physioid: ", physioid,", chemid:", chemid, ", model: ", model))
# metab_data <- getMetabData(metabid,physioid,chemid,model)
# output$sim_metab_type <- renderText(metab_data$Type)
# output$sim_metab_units <- renderText(metab_data$Units)
# output$sim_metab_val <- renderText(as.character(round(metab_data$Value,2)))
},ignoreInit = TRUE, ignoreNULL = TRUE)
# Code chunk to run the simulation.
results <- reactiveValues(pbpk=NULL,simid = NULL,mode = NULL)
observeEvent(input$run_sim,{
# print("## 30 ##")
simid <- as.integer(input$sel_sim)
# print("%% a %%")
results$simid <- simid
# get the parameters needed to run the model
# print("%% aa %%")
#print(simid)
#print(model)
model_params <- getAllParamValuesForModel(simid,model)
# print("%% b %%")
#get total volume
#active_comp <- input$ms_cmplist
# print("%% c %%")
#vol_comps <- c(active_comp,"blood")
# print("%% d %%")
# total_vol <- sum(unlist(lapply(vol_comps,
# function(x){
# input[[vol_ids[x]]]
# })
# )
# )
# print("%% e %%")
query <- sprintf("Select mc_num From SimulationsSet where simid = %i",simid)
# print("%% f %%")
mc_num <- as.integer(projectDbSelect(query)$mc_num)
# print("%% g %%")
#model_params$vals[["total_vol"]]<- total_vol
# print("%% h %%")
if (mc_num > 1){
# print("%% i %%")
MC.matrix <- getAllVariabilityValuesForModel(simid,model_params$vals,mc_num)
query <- sprintf("Select model_var from ResultNames where mode = 'mc' AND model = '%s'",
model)
mc_vars<- mainDbSelect(query)$model_var
mc_results <- lapply(mc_vars,function(x,n){
return(x = rep(NA,n))
},mc_num)
names(mc_results)<- mc_vars
for (i in 1:mc_num){
model_params$vals[colnames(MC.matrix)]<- MC.matrix[i,]
initial_values <- calculateInitialValues(model_params)
tempDF <- runFDPBPK(initial_values,model)
max_list <- unlist(lapply(mc_vars,function(x,data){
var_name <- gsub("_max","",x)
return(max(data[var_name]))
},tempDF$pbpk))
names(max_list)<- mc_vars
for (x in mc_vars){
mc_results[[x]][[i]]<- max_list[[x]]
}
updateProgressBar(session,"pb",value = i, total = mc_num)
}
results$pbpk <- as.data.frame(mc_results)
results$mode <- "MC"
updateNavbarPage(session,"menu","output")
}else{
# print("%% j %%")
#rep_flag <- all_params["rep_flag"]
#model_params <- all_params["model_params"]
initial_values <- calculateInitialValues(model_params)
# print("%% k %%")
updateProgressBar(session,"pb",value = 100, total = 100,
status = "info")
# print("%% l %%")
#initial_values$initial_params$`<NA>` <- NULL
#print(initial_values)
tempDF <- runFDPBPK(initial_values,model)
# print("%% m %%")
results$pbpk<- tempDF$pbpk
# print("%% n %%")
results$mode <- "FD"
updateNavbarPage(session,"menu","output")
}
})
#Current Parameters table under Model output
current_params <- reactive({
temp <- getAllParamValuesForModel(input$sel_sim,model = model)
# get exposure paramteres
expo_params <- data.frame("var" = expo_name_df$Name, "val" = temp$vals[expo_name_df$Var],
stringsAsFactors = F)
physio_params <- data.frame("var" = physio_name_df$Name, "val" = temp$vals[physio_name_df$Var],
stringsAsFactors = F)
current_params <- data.frame("var" = chem_name_df$Name,"val" = temp$vals[chem_name_df$Var],stringsAsFactors = F)
#current_params <- temp$a
#current_params <- cbind(gsub("ms_", "",temp$b),current_params)
return(list("cur" = current_params,"expo" = expo_params,"physio" = physio_params))
})
output$chem_params_tble <- DT::renderDT(DT::datatable(current_params()$cur,
rownames = F),
colnames=c("Variable names", "Value"))
output$expo_params_tble <- DT::renderDT(DT::datatable(current_params()$expo,
rownames = F,
colnames=c("Variable names", "Value"))
)
output$physio_params_tble <- DT::renderDT(DT::datatable(current_params()$physio,
rownames = F,
colnames=c("Variable names", "Value")))
observeEvent(input$run,{
# print("## 31 ##")
active_comp <- input$ms_cmplist
compartment_list <-c("skin","fat","muscle","bone","brain","lung","heart","gi","liver","kidney","rpf","spf")
inactive_comp <- setdiff(compartment_list,active_comp)
vol_comps <- c(active_comp,"blood")
perfc <- input$ms_perfc
total_vol <- sum(unlist(lapply(vol_comps,function(x){input[[vol_ids[x]]]})))
#exposure
if ("gi" %in% active_comp && !("liver" %in% active_comp)){
showModal(
modalDialog(
tags$h4("Invalid Compartment Configuration"),
tags$h5("Liver compartment needs to be active if GI compartment is active"),
title = "Error"
)
)
}else if (length(active_comp) == 0){
showModal(
modalDialog(
tags$h4("Invalid Compartment Configuration"),
tags$h5("At least one compartment needs to be active for the model to run."),
title = "Error"
)
)
}else if(abs(total_vol-perfc)>0.03){
showModal(
modalDialog(
tags$h4("Invalid Compartment Configuration"),
tags$h5("The total volume of all compartments does not add up to 85%"),
title = "Error"
)
)
}else if((input$ms_bdose>0 || input$ms_drdose>0) && !("gi" %in% active_comp)){
showModal(
modalDialog(
tags$h4("Invalid Compartment Configuration"),
tags$h5("GI compartment must be active for Oral and Drinking water routes of exposure"),
title = "Error"
)
)
}else{
# set volumes of inactive compartments to 1e-8 ( very low)
sapply(inactive_comp,function(x){updateNumericInput(session,vol_ids[x],value = 1e-8)})
# set blood flow of inactive compartments to 0 ( very low)
sapply(inactive_comp,function(x){updateNumericInput(session,flow_ids[x],value = 0)})
withProgress({
tempDF <- runPBPKmodel(input, total_vol,perfc)
results$pbpk<- tempDF$pbpk
},
message = "Running Simulation",
value = 0.75
)
}
}
)
observeEvent(input$btnAddData,{
# print("## 32 ##")
addDataSetUI(input$btnAddData,"Generic PBPK")
dataset$savedat <- callModule(addDataSet,input$btnAddData,"Generic PBPK")
# conc_datasets <- c("none",getDatasetNames("conc"))
# updateSelectizeInput(session,"cplt_data",choices = conc_datasets)
})
observe({
# print("## 33 ##")
if(dataset$savedat()[1]=="Yes"){
type <- "conc"
set_list <- getObservationSetChoices(type)
if(type == "conc"){
ui_id <- "cplt_data"
}else{
ui_id <- "cl_data"
}
shinyWidgets::updatePickerInput(session,ui_id,
choices = c("No Dataset"="none",set_list),
selected = "none")
dataset$savedat <- reactiveVal(c("No","None"))
# updateSelectizeInput(session,paste0("sel_scene_",set_type),choices = set_list)
}
})
# Exposure PLots data
exposureData <- reactive({
result<- as.data.frame(results$pbpk)
values <- c()
legend_names<-c("odose"= "Instantaneous Oral Dose",
"totodose"="Total Oral Dose",
"ddose"= "Instantaneous Drinking Dose",
"totddose"="Total Drinking Dose",
"ainh"="Total Inhalation Dose",
"InstInhDose"="Instantaneous Inhalation Dose")#,
#"ADRM"= "Total Dermal Dose",
#"InstDrmDose"= "Instantaneous Dermal Dose"
#)
# get exposure values for the simulation just run
simid <- results$simid
if(is.null(simid)){
bdose <- 0
ddose <- 0
idose <- 0
}else{
query <- sprintf("SELECT expoid FROM SimulationsSet Where simid = %i ;",
simid)
expoid <- projectDbSelect(query)$expoid
query <- sprintf("Select param,value FROM Exposure WHERE expoid = %i;",
expoid)
ret_data <- projectDbSelect(query)
expo_data <- setNames(as.character(ret_data$value),
ret_data$param)
bdose <- as.numeric(expo_data['bdose'])
ddose <- as.numeric(expo_data['drdose'])
idose <- as.numeric(expo_data['inhdose'])
}
if (input$r_expo_type == "act"){
if (input$ch_dose == TRUE){
if (bdose >0){
values<- c("odose",values)
}else if(ddose > 0){
values <- c("ddose",values)
}else if(idose >0){
values<- c("InstInhDose",values)
# }else if(drmdlen>0){
# values<- c("InstDrmDose",values)
}
}
if(input$ch_totdose == TRUE){
if (bdose >0){
values<- c("totodose",values)
}else if (ddose >0){
values<- c("totddose",values)
}else if(idose >0){
values<- c("ainh",values)
}
# }else if(drmdlen>0){
# values<- c("adrm",values)
#}
}
}else{
if (input$ch_dose == TRUE){
values <- c('odose','ddose','InstInhDose',values)
}
if(input$ch_totdose == TRUE){
values <- c('totodose','totddose','ainh',values)
}
}
if (exists("plot_frame")){
rm(plot_frame)
}
# check if model was ever run
if (dim(result)[1]==0){
x<- 1:10
}else{
x<- as.integer(result$time)
}
plot_frame <- data.frame(time = x)
#select appropriate variables to plot
if (dim(result)[1]==0){
plot_frame["Model not yet run"]<-rep(0,length(x))
}
else if(length(values) >0 ){
for (plt_name in values){
y<- result[[plt_name]]
plot_frame[legend_names[plt_name]] <-y
}
}else{
plot_frame["No Data Selected"]<-rep(0,length(x))
}
plot_frame <- reshape2::melt(plot_frame,id.vars = "time")
return(plot_frame)
})
# Dataset plotting
concDataset <- reactive({
if (input$cplt_data=="none"){
return(data.frame("time"=c(0),"mean"=c(0),"sd"=c(0)))#data.frame("time"=NULL,"mean"=NULL,"sd"=NULL))
}else{
obsid <- input$cplt_data
query <- sprintf("SELECT units, obs_tble FROM Observation WHERE obsid = %i",
as.integer(obsid))
obs_data <- projectDbSelect(query)
dataset <- unserialize(charToRaw(obs_data$obs_tble))
if (ncol(dataset)<3){
dataset[,"sd"]<- 0
}
names(dataset)<- c("time","mean","sd")
return(dataset)
}
})
concDatasetName <- reactive({
if (input$cplt_data=="none"){
return("No Dataset Selected")#data.frame("time"=NULL,"mean"=NULL,"sd"=NULL))
}else{
obsid <- input$cplt_data
query <- sprintf("SELECT name FROM ObservationSet WHERE obsid = %i",
as.integer(obsid))
obs_name <- projectDbSelect(query)
return(obs_name)
}
})
# Concentration plot Data
concData <- reactive({
result <- results$pbpk
units <- input$r_cplt_type
simid <- results$simid
mode <- results$mode
if(is.null(simid)){
mw <- 1000 # to keep the multiplier as 1
}else{
query <- sprintf("SELECT mc_num,chemid FROM SimulationsSet Where simid = %i ;",
simid)
chemid <- projectDbSelect(query)$chemid
mc_num <- projectDbSelect(query)$mc_num
query <- sprintf("Select value FROM Chemical WHERE chemid = %i AND param = 'mw';",
chemid)
mw <- projectDbSelect(query)$value
}
#get value multiplier based on concentration units
if(units == "um"){
multiplier <- 1000/mw
}else{
multiplier <- 1
}
result<- as.data.frame(result)
values <- c()
query <- sprintf("Select model_var,plot_var,name from ResultNames where param_set = 'conc' AND model='%s' AND mode = '%s';",model,mode)
legend_df <- mainDbSelect(query)
legend_names <- setNames(legend_df$name,legend_df$model_var)
var_names <- setNames(legend_df$model_var,legend_df$plot_var)
plot_vals<- input$cplt_comp
values <- unlist(lapply(plot_vals,function(x){var_names[x]}))
names(values)<- NULL
if (exists("plot_frame")){
rm(plot_frame)
}
# check if model was ever run
if (dim(result)[1]==0){
plot_frame<- 1:10
}else{
if(mode == "FD"){
x<- result$time
plot_frame <- data.frame("time" = result$time,
stringsAsFactors = F)
}else{
x <- 1:nrow(result)
plot_frame <- data.frame("sample" = 1:nrow(result),
stringsAsFactors = F)
}
}
# select appropriate variables to plot
if (dim(result)[1]==0){
plot_frame["Model not yet run"]<-rep(0,length(x))
}
else if(length(values) >0 ){
for (plt_name in values){
y<- result[[plt_name]] * multiplier
plot_frame[[legend_names[plt_name]]] <-y
}
}else{
plot_frame["No Data Selected"]<-rep(0,length(x))
}
if (mode == "FD"){
plot_frame <- reshape2::melt(plot_frame,id.vars = "time")
}else{
plot_frame <- reshape2::melt(plot_frame,id.vars = "sample")
}
return(plot_frame)
})
#Concentration table data
conc_tble_data <- reactive({
mode <- results$mode
plt_data<- concData()
return(reshapePlotData(plt_data,mode))
})
amtData <- reactive({
result <- results$pbpk
units <- input$r_aplt_type
simid <- results$simid
mode <- results$mode
if(is.null(simid)){
mw <- 1000 # to keep the multiplier as 1
}else{
query <- sprintf("SELECT mc_num,chemid FROM SimulationsSet Where simid = %i ;",
simid)
chemid <- projectDbSelect(query)$chemid
mc_num <- projectDbSelect(query)$mc_num
query <- sprintf("Select value FROM Chemical WHERE chemid = %i AND param = 'mw';",
chemid)
mw <- projectDbSelect(query)$value
}
#get value multiplier based on concentration units
if(units == "um"){
multiplier <- 1000/mw
}else{
multiplier <- 1
}
values <- c()
query <- sprintf("Select model_var,plot_var,name from ResultNames where param_set = 'amt' AND model='%s' AND mode = '%s';",model,mode)
legend_df <- mainDbSelect(query)
legend_names <- setNames(legend_df$name,legend_df$model_var)
var_names <- setNames(legend_df$model_var,legend_df$plot_var)
plot_vals<- input$aplt_comp
values <- unlist(lapply(plot_vals,function(x){var_names[x]}))
names(values)<- NULL
if (exists("plot_frame")){
rm(plot_frame)
}
# check if model was ever run
if (dim(result)[1]==0){
plot_frame<- 1:10
}else{
if(mode == "FD"){
x<- result$time
plot_frame <- data.frame("time" = result$time,
stringsAsFactors = F)
}else{
x <- 1:nrow(result)
plot_frame <- data.frame("sample" = 1:nrow(result),
stringsAsFactors = F)
}
}
# select appropriate variables to plot
if (dim(result)[1]==0){
plot_frame["Model not yet run"]<-rep(0,length(x))
}
else if(length(values) >0 ){
for (plt_name in values){
y<- result[[plt_name]] *multiplier
plot_frame[[legend_names[plt_name]]] <-y
}
}else{
plot_frame["No Data Selected"]<-rep(0,length(x))
}
if (mode == "FD"){
plot_frame <- reshape2::melt(plot_frame,id.vars = "time")
}else{
plot_frame <- reshape2::melt(plot_frame,id.vars = "sample")
}
return(plot_frame)
})
#Concentration table data
amt_tble_data <- reactive({
mode <- results$mode
plt_data<- amtData()
return(reshapePlotData(plt_data,mode))
})
AUCData <- reactive({
#getAUCPlotData(input,results$pbpk)
})
balData<- reactive({
result<- as.data.frame(results$pbpk)
# check if model was ever run
if (dim(result)[1]==0){
x<- 1:10
}else{
x<- result$time
}
plot_frame<-data.frame(time = x)
# select appropriate variables to plot
if (dim(result)[1]==0){
plot_frame["Model not yet run"]<-rep(0,length(x))
}else{
plot_frame["Mass Balance"]<- result$mbal
}
plot_frame <- reshape2::melt(plot_frame,id.vars = "time")
return(plot_frame)
})
# output$concplt <- plotly::renderPlotly(plotly::ggplotly(ggplot()
# +geom_line(data = concData(), aes(x=time,y=value,color = variable))
# +geom_pointrange(data = concDataset(),aes(x = time,y = mean, ymin = mean-sd ,ymax = mean+sd,fill = "Dataset (mg/L)"))
#
# +labs(x="Time (h)",y="Concentration")
# +theme(axis.text=element_text(size = 15),axis.title=element_text(size = 25),legend.text=element_text(size=15),legend.title=element_blank())))
concplt <- reactive({
if (results$mode == "FD"){
plotly::plot_ly()%>%
plotly::add_trace(data = concData(),x = ~time,
y = ~value,color = ~variable,
type = "scatter",mode = "lines") %>%
plotly::add_trace(data = concDataset(),x = ~time,y = ~mean,
type = "scatter",mode = "markers",
name = concDatasetName(),
marker = list(color = "#000"),
error_y = list(array= ~sd,
color = '#000')
)%>%
plotly::layout(xaxis = list(title = ('Time(h)')),
yaxis = list(title = (ifelse(input$r_cplt_type=="um",'Concentration (\u00B5M)',
'Concentration (mg/L)'))))
}else{
plotly::plot_ly()%>%
plotly::add_trace(data = concData(),
y = ~value,color = ~variable,
type = "box")%>%
plotly::layout(yaxis = list(title = (ifelse(input$r_cplt_type=="um",
'Concentration (\u00B5M)',
'Concentration (mg/L)'))
)
)
}
})
amtplt <- reactive({
if (results$mode == "FD"){
plotly::plot_ly() %>%
plotly::add_trace(data = amtData(),x =~time,
y= ~value,color = ~variable,
type = "scatter",mode="lines")%>%
plotly::layout(xaxis = list(title = ('Time(h)')),
yaxis = list(title = (ifelse(input$r_aplt_type=="um",
'Amount (\u00B5moles)',
'Amount (mg)')))
)
# plotly::ggplotly(ggplot(amtData(), aes(x=time,y=value,color = variable))+geom_line()
# +labs(x="Time (h)",y="Amount")
# +theme(axis.text=element_text(size = 15),axis.title=element_text(size = 25),legend.text=element_text(size=15),legend.title=element_blank()))
}else{
plotly::plot_ly()%>%
plotly::add_trace(data = amtData(),
y = ~value,color = ~variable,
type = "box")%>%
plotly::layout(yaxis = list(title = (ifelse(input$r_aplt_type=="um",
'Concentration (\u00B5M)',
'Concentration (mg/L)'))
)
)
}
})
output$concplt <- plotly::renderPlotly(concplt())
output$exposureplt <- plotly::renderPlotly(plotly::ggplotly(ggplot(exposureData(), aes(x=time,y=value,color = variable))+geom_line()
+labs(x="Time (h)",y="Amount(umoles)")
+theme(axis.text=element_text(size = 15),axis.title=element_text(size = 25),legend.text=element_text(size=15),legend.title=element_blank())))
output$amtplt <- plotly::renderPlotly(amtplt())
# output$aucplt <- renderPlot(ggplot(AUCData(), aes(x=time,y=value,color = variable))+geom_line()
# +labs(x="Time (h)",y="AUC (mg*h/L)")
# +theme(axis.text=element_text(size = 15),axis.title=element_text(size = 25),legend.text=element_text(size=15),legend.title=element_blank()))
output$balplt <- renderPlot(ggplot(balData(), aes(x=time,y=value,color = variable))+geom_line()
+labs(x="Time (h)",y="Amount (umoles)")
#+ylim(-1e-5,1e-5)
+theme(axis.text=element_text(size = 15),axis.title=element_text(size = 25),legend.position="none")
)
#data tables
output$conctble <- DT::renderDT(conc_tble_data())#reshapePlotData(concData()))
output$expotble <- DT::renderDT(reshapePlotData(exposureData()))
output$amttble <- DT::renderDT(amt_tble_data())#reshapePlotData(amtData()))
output$baltble <- DT::renderDT(reshapePlotData(balData()))
#output$auctble <- renderDataTable(reshapePlotData(AUCData()))
#Download Plots data Tables
output$expodwnld <- downloadHandler(
filename = function(){
return("expo_data.csv")
},
contentType = "text/csv",
content = function(file) {
write.csv(reshapePlotData(exposureData()), file)
}
)
output$cdwnld <- downloadHandler(
filename = function(){
return("conc_data.csv")
},
contentType = "text/csv",
content = function(file) {
write.csv(reshapePlotData(concData()), file)
}
)
output$amwnld <- downloadHandler(
filename = function(){
return("amt_data.csv")
},
contentType = "text/csv",
content = function(file) {
write.csv(reshapePlotData(amtData()), file)
}
)
output$aucdwnld <- downloadHandler(
filename = function(){
return("auc_data.csv")
},
contentType = "text/csv",
content = function(file) {
write.csv(reshapePlotData(AUCData()), file)
}
)
output$cmbaldwnld <- downloadHandler(
filename = function(){
return("balance_data.csv")
},
contentType = "text/csv",
content = function(file) {
write.csv(reshapePlotData(results()), file)
}
)
# power button to shut down the app
observeEvent(input$menu,{
# print("## 34 ##")
if(input$menu=="stop"){
shinyWidgets::confirmSweetAlert(session,"close_dialog", "Close Application",
"Any changes will not be saved. Proceed?",type = "info",danger_mode = T)
}else if(input$menu == "save"){
shinyWidgets::confirmSweetAlert(session,"save_dialog", "Save Project",
"Unsaved changes will be lost. Proceed?",type = "info",danger_mode = T)
}
})
observeEvent(input$close_dialog,{
# print("## 35 ##")
if (input$close_dialog){
stopApp()
}else{
updateNavbarPage(session,"menu","setup")
}
})
observeEvent(input$save_dialog,{
# print("## 36 ##")
if(input$save_dialog){
saveProject()
}else{
updateNavbarPage(session,"menu","setup")
}
})
})
calculateInitialValues <- function(params_list){
params <- params_list$vals
params <- params[which(grepl("[-]?[0-9]+[.]?[0-9]*|[-]?[0-9]+[L]?|[-]?[0-9]+[.]?[0-9]*[eE][0-9]+",params))]
params <- lapply(params,function(x){as.numeric(x)})
initial_params <- within(as.list(params),{
perfc <- 1
total_vol <- vlivc + vfatc + vkdnc + vrpfc + vspfc
#Scaled Tissue Volumes
vfat <- vfatc*(perfc/total_vol)*bw
vkdn <- vkdnc*(perfc/total_vol)*bw
vliv <- vlivc*(perfc/total_vol)*bw
vrpf <- vrpfc*(perfc/total_vol)*bw
vspf <- vspfc*(perfc/total_vol)*bw
#Total Fractional Perfusion
total_perf <- qfatc+qkdnc+qlivc+qrpfc+qspfc # This does not include flow to GI since that is a part of liver venous flow
#Scaled Perfusion
qfat <- qfatc*(1/total_perf)*qc
qkdn <- qkdnc*(1/total_perf)*qc
qliv <- qlivc*(1/total_perf)*qc
qrpf <- qrpfc*(1/total_perf)*qc
qspf <- qspfc*(1/total_perf)*qc
tstop <- tstart+sim_dur
#calculate gut uptake limit
gul <- ifelse(qc*pbldw > qrpf,qg,qc*pbldw)
})
#function for dosing
mw <- initial_params[["mw"]]
bw <- initial_params[["bw"]]
#Chemical Inspiration
cins <- initial_params[["cins"]]
tstart <- initial_params[["tstart"]]
tstop <- initial_params[["tstop"]]
times <- seq(tstart,tstop,by=0.1)
eventDat <- list("time"= 0)
state <- c(
cfat = 0.0,
cliv = 0.0,
cspf = 0.0,
crpf = 0.0,
ckdn = 0.0,
cmet = 0.0,
ains = 0.0,
insswch = 0.0)
initial_values <- list("evnt_data"= eventDat,
"initial_params"= initial_params[params_list$names],
"times"=times,
"tstop"=tstop,"tstart"=tstart,
"state"= state)
return(initial_values)
}
fishPBPK_initParms <- function(newParms = NULL) {
parms <- c(
bw = 0,
qc = 0,
qg = 0,
vfatc = 0,
qfatc = 0,
pfat = 0,
vlivc = 0,
qlivc = 0,
pliv = 0,
vkdnc = 0,
qkdnc = 0,
pkdn = 0,
vrpfc = 0,
qrpfc = 0,
prpf = 0,
vspfc = 0,
qspfc = 0,
pspf = 0,
frspfkdn = 0.6,
vfat = 0,
vkdn = 0,
vliv = 0,
vrpf = 0,
vspf = 0,
qfat = 0,
qkdn = 0,
qliv = 0,
qrpf = 0,
qspf = 0,
vmax = 0,
km = 1e-10,
cins = 0,
pbldw = 1e10,
gul = 1,
)
if (!is.null(newParms)) {
if (!all(names(newParms) %in% c(names(parms)))) {
stop("illegal parameter name")
}
parms[names(newParms)] <- newParms
}
parmsfishPBPK <- within(as.list(parms), {
})
out <- .C("getParmsfishPBPK", as.double(parms),
out=double(length(parms)),
as.integer(length(parms)))$out
names(out) <- names(parms)
out
}
fishPBPK_Outputs <- c(
"cv",
"ca",
"mbal"
)
fishPBPK_initStates <- function(parms, newStates = NULL) {
Y <- c(
cfat = 0.0,
cliv = 0.0,
cspf = 0.0,
crpf = 0.0,
ckdn = 0.0,
cmet = 0.0,
ains = 0.0,
insswch = 0.0
)
if (!is.null(newStates)) {
if (!all(names(newStates) %in% c(names(Y)))) {
stop("illegal state variable name in newStates")
}
Y[names(newStates)] <- newStates
}
.C("initStatefishPBPK", as.double(Y));
Y
}
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