pairwise_epistasis_lik: pairwise_epistasis_lik

In Townsend-Lab-Yale/cancereffectsizeR: Calculate Cancer Effect Size

pairwise_epistasis_lik

Description

For a pair of variants (or two groups of variants), creates a likelihood function for a model of pairwise epistasis with a "strong mutation, weak selection" assumption.

Usage

pairwise_epistasis_lik(with_just_1, with_just_2, with_both, with_neither)

Arguments

with_just_1	two-item list of baseline rates in v1/v2 for tumors with mutation in just the first variant(s)
with_just_2	two-item list of baseline rates in v1/v2 for tumors with mutation in just the second variant(s)
with_both	two-item list of baseline rates in v1/v2 for tumors with mutation in both
with_neither	two-item list of baseline rates in v1/v2 for tumors with mutation n neither

Details

The arguments to this function are automatically supplied by ces_epistasis() and ces_gene_epistasis().

Value

A likelihood function

Townsend-Lab-Yale/cancereffectsizeR documentation built on April 28, 2024, 6:14 p.m.