#' Function to fit a multivariable fractional polynomial model to a data.frame or an expressionSet
#'
#' Fits and mfp model for each row in data using mfp package
#'
#' @param data_m \code{ExpressionSet} or data.frame with samples as columns and observations as rows could be an ExpressionSet(modif!)
#' @param vars_df data.frame with sampes as rows and variables as columns
#' @param df degrees of freedom for mfp, default 4, 1 would be linear
#' @param alpha sets the FP selection level for all predictors. Values for individual predictors may be changed via the fp function in the formula.
#' @param select select: sets the variable selection level for all predictors. Values for individual predictors may be changed via the fp function in the formula.
#' @param cores cores in case of parallelization (no windows)
#' @param verbose logical to verbose (comment) the steps of the function, default(FALSE)
#'
#' @examples to be built
fit.mfp <- function(data = data_m,
vars_df = vars_df,
df = 4L,
alpha = 0.05,
select = 0.05,
cores = 1L,
verbose = FALSE,
...)
{
# Formula structure for the models: only for numerical vars
vars_numeric <- names(vars_df)
formula <- as.formula(paste0("y ~ ", paste0("fp(", vars_numeric, ", df = ", df, " )", collapse = " + ")))
fmodel <- function(y, vars_df, probe)
{
if(verbose) print(paste("Analyzing probe var ", probe))
# Prepare data whith the corresponding outcome:
data <- data.frame(cbind(y = y, vars_df))
data <- data[complete.cases(data),]
colnames(data) <- c("y", colnames(vars_df))
# Fit the model:
mod <- try(mfp(formula, alpha=alpha, select = select, rescale = FALSE, verbose = FALSE, data = data), TRUE)
# Get model performances:
if(class(mod)[1] == "try-error"){
vars <- NA
vars_n <- NA
form <- NA
cor2 <- NA
p <- NA
aic <- NA
} else {
vars <- try(unique(as.character(str_sub(word(names(mod$coefficients)[-1],1), start = 1, end = -3))), TRUE) #aix? nom?s extrau totes les vars continues
vars_n <- try(as.integer(sum(!is.na(vars))), TRUE)
form <- try(mod$formula)
y_hat <- predict(mod)
ct <- cor.test(y_hat, data$y, use = "pairwise.complete.obs")
cor2 <- ifelse(vars_n == 0, NA, try(round((ct$estimate)^2,4), TRUE))
p <- ifelse(vars_n == 0, NA, try((ct$p.value)^2, TRUE))
aic <- round(mod$aic,4)
gc(reset = TRUE)
}
# Data frame of the results:
taula <- try(data.frame(cbind(probe = probe, vars_n = vars_n, aic = aic, Cor2 = cor2, p = p), stringsAsFactors = FALSE), TRUE)
result <- try(list(table = taula, selected_vars = vars, final_formula = form), TRUE)
result
}
if(cores>1){
results <- try(mcmapply(function(y, ny) fmodel(y = y, vars_df = vars_df, probe = ny),
y = apply(data, 1, list),
ny = rownames(data),
SIMPLIFY = FALSE, mc.cores = cores), TRUE)
} else {
results <- try(mapply(function(y, ny) fmodel(y = y, vars_df = vars_df, probe = ny),
y = apply(data, 1, list),
ny = rownames(data),
SIMPLIFY = FALSE), TRUE)
}
return(results)
}
# ===============================================================================
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