adjust_for_futility_rule: Adjust Dose-Response Table when Futility Rule Invoked

In jiyingz/clinicalMPI: The novel modified probability interval (mPI) phase I clinical trial design

Adjust Dose-Response Table when Futility Rule Invoked

Description

Adjust dose availabilities given that the futility rule was invoked, if dose sample size >= 6 (if sample size < 6, choose to stay and explore dose further, so no availabilities are changed). The dose that invoked the futility rule and any higher doses will be made unavailable for future consideration.

Usage

dose_info = adjust_for_futility_rule(60, dose_info) #if dose level 60 invoked futility rule

Arguments

dose	A numeric dose level that violated the futility rule
dose_info	Dataframe containing [dose level | availability | N_d | X_d | Y_d | Z_d | pf | pe | pt]

Value

Updated dose-response table dataframe with adjusted availabilities

jiyingz/clinicalMPI documentation built on Jan. 19, 2024, 5:58 a.m.