select_final_dose: Final Dose Selection

In jiyingz/clinicalMPI: The novel modified probability interval (mPI) phase I clinical trial design

Final Dose Selection

Description

Select the final dose out of available doses that has the highest utility.

Usage

select_final_dose(dose_info, stopping_rule = FALSE, filter = 0.5)

Arguments

dose_info	Dataframe containing [dose level | availability | N_d | X_d | Y_d | Z_d | pf | pe | pt]
sample_size	Cumulative sample size at trial end
max_samp_size	Maximum sample size for trial
stopping_rule	Whether or not a stopping rule was invoked
filter	Posterior sum threshold to determine dose availability for final selection (pf+pt <= filter)

Details

No final dose is recommended if no doses are available, any stopping rules have been invoked, or no dose meets the selection criteria of pf+pt <= filter (e.g. filter = 0.5). The latter criteria is to exclude doses with too high toxicity or futility, but have not invoked safety or futility rules. Another alternative is to exclude doses with estimated chances of toxicity and futility above the equivalence intervals, but this has been found to be too strict a criteria and results in no dose recommendation too often through simulation studies.

Value

The final dose recommendation, or -99 if no dose was selected

jiyingz/clinicalMPI documentation built on Jan. 19, 2024, 5:58 a.m.