make_intervals: Probability Intervals (Regions) Setup

In jiyingz/clinicalMPI: The novel modified probability interval (mPI) phase I clinical trial design

Probability Intervals (Regions) Setup

Description

Make probability intervals given the target futility and toxicity level threshold parameters

Usage

intervals = make_intervals(PF=0.2, PF_tolerance=0.05, eta=0.8, PT=0.2, PT_tolerance=0.05, zeta=0.8)

pf_matrix = intervals$pf_matrix

pt_matrix = intervals$pt_matrix

Arguments

PF	Target tolerable futility probability
PF_tolerance	Half-length of futility equivalence interval (epsilon_F)
eta	Upper futility threshold beyond which invokes the futility rule
PT	Target tolerable toxicity probability
PT_tolerance	Half-length of toxicity equivalence interval (epsilon_T)
zeta	Upper toxicity threshold beyond which invokes the safety rule

Value

A list containing:

• pf_matrix – matrix containing start and end points of p_f intervals

• pt_matrix – Matrix containing start and end points of p_t intervals

jiyingz/clinicalMPI documentation built on Jan. 19, 2024, 5:58 a.m.