check_stopping_rules: Check Stopping Rules

In jiyingz/clinicalMPI: The novel modified probability interval (mPI) phase I clinical trial design

Check Stopping Rules

Description

check if dose invokes stopping rules:

• Maximum sample size reached

• No doses available for evaluation

• Lowest dose is too toxic

• Highest dose is too futile

• Decision is DU/EU and no doses in direction to move are available for evaluation

Usage

check_stopping_rules(80, dose_info, 15, 24, "D", closest_lower_dose = 60)

Arguments

dose	A numeric dose level (assumed to be available)
dose_info	Dataframe containing [dose level | availability | N_d | X_d | Y_d | Z_d | pf | pe | pt]
sample_size	Current sample size (across all doses)
max_samp_size	Maximum sample size for entire trial
decision	Decision, one of "DU", "D", "S", "E", or "EU". Defaults to NA.
closest_lower_dose	If decision is to de-escalate, the closest available lower dose, -Inf if none available. Defaults to NA.
closest_higher_dose	If decision is to escalate, the closest available higher dose, Inf if none available. Defaults to NA.

Value

Boolean T/F whether any stopping rules were violated

jiyingz/clinicalMPI documentation built on Jan. 19, 2024, 5:58 a.m.