make_decision_table: Make Decision Table

In jiyingz/clinicalMPI: The novel modified probability interval (mPI) phase I clinical trial design

Make Decision Table

Description

Produces the pre-smoothed decision table for a certain dose sample size using given parameters and thresholds. The decision table should be generalizable to any dose level. Safety is valued over efficacy, so any estimates exceeding the toxicity tolerance will call for de-escalation.

IMPORTANT: The decision table must be named in the following format to run simulations: "decision_table#" where #=N.

Usage

make_decision_table(15, PF = 0.2, PF_tolerance = 0.05, eta = 0.8, PT = 0.2, PT_tolerance = 0.05, zeta = 0.8)

Arguments

N	Number of patients tested at a dose
PF	Target tolerable futility probability
PF_tolerance	Half-length of futility equivalence interval (epsilon_F)
eta	Upper futility threshold beyond which invokes the futility rule
PT	Target tolerable toxicity probability
PT_tolerance	Half-length of toxicity equivalence interval (epsilon_T)
zeta	Upper toxicity threshold beyond which invokes the safety rule

Value

A matrix containing the decision table. Futility counts are on the row axis, and toxicity counts are on the column axis.

jiyingz/clinicalMPI documentation built on Jan. 19, 2024, 5:58 a.m.