simulateAssay: Simulate selection assay

In jweile/tileseqMave: TileSeq MAVE Analysis pipeline

Simulate selection assay

Description

This simulates the effects of a growth-based fitness assay. It samples a pool of cells of the desired size and applies fitness effects with a pre-determined amount of noise. It then outputs the clone frequencies in the pre- and post-selection pool

Usage

simulateAssay(params, plasmidPools, trueFit, n, sd = 0.01, t = 3)

Arguments

params	the parameter sheet
trueFit	the output of simulateFitness()
n	The size of the pre-selection pool (number of cells)
sd	the standard deviation of the noise affecting the growth assay.
t	the selection time in generations
pool	the output of simulatePool()

Value

a list of vectors containing the clone frequencies in the pre- and post-selection pool

jweile/tileseqMave documentation built on April 5, 2024, 4:51 p.m.