simulateFitness: Simulate Clone fitness

In jweile/tileseqMave: TileSeq MAVE Analysis pipeline

Simulate Clone fitness

Description

This function generates assay fitness values for clones and their variants. It outputs a list with two elements: (i) a table listing the fitness effects of All possible nucleotide changes, and (ii) a function that calculates the true fitness of any given clone given its variant combination. Currently, this does not simulate genetic interactions, but simply uses multiplicativity of fitness. It also currently does not simulate hypercomplementation effects.

Usage

simulateFitness(params, pool, fitBias = 0, fitSpread = 4)

Arguments

params	The parameter sheet
pool	the output of simulatePool()
lofFreq	the frequency of loss-of-function effects to simulate
hypoFreq	the frequency of hypomorphic effects to simulate

jweile/tileseqMave documentation built on April 5, 2024, 4:51 p.m.