masato-ogishi/Repitope: Epitope immunogenicity prediction through in silico TCR-peptide contact potential profiling

In silico screening of immunogenic epitopes among the vast amount of MHC-loaded peptides is a critical step toward effective precision immunotherapy. Although various sequence-based prediction models have been proposed, none of them has ever achieved meaningful accuracy and robustness. Here, we developped a framework that enables accurate classification of immunogenic epitopes and non-immunogenic MHC binders through simulating intermolecular contacts between MHC-presented peptides and TCR repertoire.

install.packages("remotes")
remotes::install_github("masato-ogishi/Repitope")