masato-ogishi/Repitope: Epitope immunogenicity prediction through in silico TCR-peptide contact potential profiling
Version 1.3.0

In silico screening of immunogenic epitopes among the vast amount of MHC-loaded peptides is a critical step toward effective precision immunotherapy. Although various sequence-based prediction models have been proposed, none of them has ever achieved meaningful accuracy and robustness. Here, we developped a framework that enables accurate classification of immunogenic epitopes and non-immunogenic MHC binders through simulating contacts between MHC-presented peptides and public human TCR repertoire.

Getting started

Package details

AuthorMasato Ogishi
MaintainerMasato Ogishi <[email protected]>
LicenseMIT + file LICENSE
Version1.3.0
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("masato-ogishi/Repitope")
masato-ogishi/Repitope documentation built on Oct. 9, 2018, 7 a.m.