RunPennCNV: RunPennCNV

Description Usage Arguments Details Value Author(s) Source Examples

Description

RunPennCNV: Run the pennCNV algorithm.

Usage

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RunPennCNV(PathRawData = "~/CNVs/MockData/PKU/Data", MINNumSNPs = 20,
  Pattern = ".*Mock.*\\.tab$", Cores = 20, Skip = 0,
  Normalization = FALSE, PFB = "NO",
  HMM = "/media/NeoScreen/NeSc_home/share/Programs/penncnv/lib/hhall.hmm",
  Path2PennCNV = "/media/NeoScreen/NeSc_home/share/Programs/penncnv/",
  penalty = 60, Quantile = TRUE, QSpline = TRUE, sd = 0.15,
  PennCNVFormat = FALSE, RemoveTmpfiles = TRUE)

Arguments

PathRawData:

The path to the raw data files containing Log R Ratio (LRR) and B Allele Frequency (BAF) values.

MINNumSNPs:

Minimum number of SNPs per CNV, default = 20.

Pattern:

File pattern in the PathRawData. Example: "*.txt".

Cores:

Number of cores used; default = 20.

Skip:

Integer, the number of lines of the data file to be skipped before beginning to read the data, default = 0.

Normalization:

Unknown, default = FALSE.

PFB:

Vector population frequency 0 to 1 for each SNP in the array, default = NO.

HMM:

Unknown, default = Unknown.

Path2PennCNV:

The path to the pennCNV algorithm.

Penalty:

The coefficient of the penalty for degrees of freedom in the GCV criterion. From smooth.spline stats, default = 60.

Quantile:

Logical, if quantile normalization should be applied or not, default = TRUE.

QSpline:

Logical, if a cubic smoothing spline should be used to normalize the data, default = TRUE.

Sd:

numeric, LRR standard deviation (sd) for the quantile nomarlization, default = 0.15.

PennCNVFormat:

Unknown, default = FALSE.

RemoveTmpfiles:

Unknown, default = TRUE.

Details

Specifically designed to handle noisy data from amplified DNA on phenylketonuria (PKU) cards. The function is a pipeline using many subfunctions.

Value

Data frame with predicted CNVs.

Author(s)

Marcelo Bertalan, Louise K. Hoeffding.

Source

http://biopsych.dk/iPsychCNV

Examples

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Unknown.

mbertalan/iPsychCNV documentation built on May 22, 2019, 12:19 p.m.