The 'minimum distance' is the minimum signed absolute difference of the parental log R ratios and the offspring log R ratios. Specifically, let |O-F| denote the absolute difference in the log R ratios comparing offspring to father and |O-M| the absolute difference in the log R ratios comparing offspring to mother. The minimum distance at a marker is the signed minimum of |O-M| and |O-F|. After segmentation of the minimum distance, non-zero segments can indicate a de novo difference in the log R ratio of the offspring and either parent. For example, a positive minimum distance suggests that the log R ratio from the offspring is greater than the log R ratio of either parent.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 | calculateMindist(object, ...)
## S4 method for signature 'TrioSet'
calculateMindist(object, verbose = TRUE, ...)
## S4 method for signature 'TrioSetList'
calculateMindist(object)
## S4 method for signature 'list'
calculateMindist(object, outdir = ldPath(), ...)
## S4 method for signature 'arrayORff_array'
calculateMindist(object, outdir, center, ...)
## S4 method for signature 'matrix'
calculateMindist(object, ...)
|
object |
see |
... |
Ignored |
verbose |
logical. Whether to display messages indicating progress. |
outdir |
character string indicating path to save output |
center |
ignored |
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