Same as QTL_BetaBin except sizeFactor estimated by Median of ratio method was used to scale library size instead of total coverage.
1 2 3 4 | QTL_BetaBin2(MeRIPdata, vcf_file, BSgenome = BSgenome.Hsapiens.UCSC.hg19,
testWindow = 1e+05, Chromosome, Range = NULL, Covariates = NULL,
AdjustGC = TRUE, PCsToInclude = 0, normalizeGenotype = FALSE,
thread = 1)
|
MeRIPdata |
The MeRIP.Peak object |
vcf_file |
The vcf file for genotype. The chromosome position must be sorted!! |
BSgenome |
The BSgenome object. This needs to match the genome version of the gtf files. |
testWindow |
Integer. Test SNPs in <testWindow> bp window flanking the peak. |
Chromosome |
The chromsome to run QTL test. |
Range |
The position range on a chromosome to test. |
Covariates |
The matrix for covariates to be included in the test. |
AdjustGC |
Logic. Choose whether explicitly adjust GC bias. |
normalizeGenotype |
Logic. Choose whether genotype is normalized to mean = 0, var = 1 before regression. |
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