Bliss: Calculate Bliss Synergy Score

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Calculate Bliss Synergy Score

Description

Bliss calculates the synergy score matrix for a block of drug combination by using a drug interaction reference model introduced by C. I. Bliss in 1939.

Usage

Bliss(response)

Arguments

response

A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.

Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The expected effect of two drugs acting independently". The Bliss reference effect y = 1 - product_all_drug(1-%Inhibition) * 100.

Value

A data frame containing the concentrations for drugs, reference effect and synergy score estimated by Bliss model.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

References

• Yadav B, Wennerberg K, Aittokallio T, Tang J. (2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Comput Struct Biotechnol J, 13:504– 513.

• Bliss, C. I. (1939). The toxicity of poisons applied jointly. Annals of Applied Biology, 26(3):585–615.

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response <- data$response[data$response$block_id == 1,
                          c("conc1", "conc2", "response")]
Bliss.score <- Bliss(response)

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.