CalculateRI: Calculate Relative Inhibition (RI) for Dose-Response Curve

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Calculate Relative Inhibition (RI) for Dose-Response Curve

Description

Function CalculateRI calculates cell line sensitivity to a drug or a combination of drugs from dose response curve.

Usage

CalculateRI(df)

Arguments

df	A data frame. It contains two variables: dose the concentrations of drugs. response the response of cell lines at corresponding doses. We use inhibition rate of cell line growth to measure the response.

Details

This function measures the sensitivity by calculating the Area Under Curve (AUC) according to the dose response curve. The lower border is chosen as lowest non-zero concentration in the dose response data.

Value

A numeric value. It is the RI score for input dose-response curve.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

Examples

# LL.4
df <- data.frame(dose = c(0, 0.1954, 0.7812, 3.125, 12.5, 50),
                 response = c(2.95, 3.76, 18.13, 28.69, 46.66, 58.82))
RI <- CalculateRI(df)

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.