dot-ScoreCurve_L4: CSS Facilitate Function - .ScoreCurve for Curves Fitted by...

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

CSS Facilitate Function - .ScoreCurve for Curves Fitted by L.4 Model

Description

This function is used to score sensitivities given either a single-agent or a fixed conc (combination) columns. The function calculates the AUC of the log10-scaled dose-response curve.

Usage

.ScoreCurve_L4(b, c, d, e, c1, c2, t)

Arguments

b	A numeric value, fitted parameter b from L.4 model.
c	A numeric value, fitted parameter c from L.4 model.
d	A numeric value, fitted parameter d from L.4 model.
e	A numeric value, fitted parameter e from L.4 model.
c1	A numeric value, log10(min conc) (this is the minimal nonzero concentration).
c2	A numeric value, log10(max conc) (this is the maximal concentration).
t	A numeric value, threshold (usually set to zero).

Value

A numeric value, RI or CSS scores.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.