CorrectBaseLine: Base Line Correction for Drug Combination Matrix

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Base Line Correction for Drug Combination Matrix

Description

CorrectBaseLine adjusts the base line of drug combination dose-response matrix to make it closer to 0.

Usage

CorrectBaseLine(response, method = c("non", "part", "all"))

Arguments

response	A drug combination dose-response matrix. It's column name and row name are representing the concentrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.
method	A character value. It indicates the method used for baseline correction. Available values are: non No baseline correction. part Adjust only the negative values in the matrix. all Adjust all values in the matrix.

Value

A matrix which base line have been adjusted.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response <- data$response[data$response$block_id == 1, ]
adjusted <- CorrectBaseLine(response, method = "part")

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.