dot-ScoreCurve: CSS Facilitate Function - .ScoreCurve for Curves Fitted by...

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

CSS Facilitate Function - .ScoreCurve for Curves Fitted by LL.4 Model

Description

New function used to score sensitivities given either a single-agent or a fixed conc (combination) columns. The function calculates the AUC of the log10-scaled dose-response curve. IMPORTANT: note that with LL.4 calls, this value is already logged since the input concentrations are logged.

Usage

.ScoreCurve(b, c, d, m, c1, c2, t)

Arguments

b	A numeric value, fitted parameter b from LL.4 model.
c	A numeric value, fitted parameter c from LL.4 model.
d	A numeric value, fitted parameter d from LL.4 model.
m	A numeric value, relative IC50 for the curve. log10(e), where e is the fitted parameter e from LL.4 model.
c1	A numeric value, log10(min conc) (this is the minimal nonzero concentration).
c2	A numeric value, log10(max conc) (this is the maximal concentration).
t	A numeric value, threshold (usually set to zero).

Value

A numeric value, RI or CSS scores.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.