HSA: Calculate HSA Synergy Score

In shuyuzheng/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Calculate HSA Synergy Score

Description

HSA calculates the synergy score matrix for a block of drug combination by using Highest Single Agent (HSA) reference model.

Usage

HSA(response)

Arguments

response

A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.

Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The reference effect of drug combination is the maximal single drug effect".

Value

A data frame containing the concentrations for drugs, reference effect and synergy score estimated by HSA model.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

References

• Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.

• Berenbaum MC. (1989). What is synergy? Pharmacol Rev 1990 Sep;41(3):422.

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response <- data$response[data$response$block_id == 1, 
                          c("conc1", "conc2", "response")]
HSA.score <- HSA(response)

shuyuzheng/synergyfinder documentation built on Feb. 20, 2023, 11:33 p.m.