Low-level function to estimate size factors with robust regression.

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Description

This function is borrowed from DESeq.

Usage

1

Arguments

counts

a matrix or data frame of counts, i.e., non-negative integer values

locfunc

a function to compute a location for a sample. By default, the median is used.

Details

Given a matrix or data frame of count data, this function estimates the size factors as follows: Each column is divided by the geometric means of the rows. The median (or, if requested, another location estimator) of these ratios (skipping the genes with a geometric mean of zero) is used as the size factor for this column. Typically, you will not call this function directly.

Value

a vector with the estimates size factors, one element per column

Author(s)

Simon Anders

References

Simon Anders, Wolfgang Huber: Differential expression analysis for sequence count data. Genome Biology 11 (2010) R106, http://dx.doi.org/10.1186/gb-2010-11-10-r106

Examples

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