CompareWilcox: CompareWilcox

In ChromSCape: Analysis of single-cell epigenomics datasets with a Shiny App

Description

CompareWilcox

Usage

CompareWilcox(
  dataMat = NULL,
  annot = NULL,
  ref_group = NULL,
  groups = NULL,
  featureTab = NULL,
  block = NULL
)

Arguments

dataMat	A raw count matrix
annot	A cell annotation data.frame
ref_group	List with cells in reference group(s)
groups	List with cells in group(s) to test
featureTab	data.frame with feature annotation
block	Use a blocking factor to conteract batch effect ?

Value

A dataframe containing the foldchange and p.value of each feature

Author(s)

Eric Letouze & Celine Vallot

Examples

data("scExp")
scExp_cf = correlation_and_hierarchical_clust_scExp(scExp)
scExp_cf = choose_cluster_scExp(scExp_cf,nclust=2,consensus=FALSE)
featureTab = as.data.frame(SummarizedExperiment::rowRanges(scExp_cf))
rownames(featureTab) = featureTab$ID
ref_group = list("C1"=scExp_cf$cell_id[which(scExp_cf$cell_cluster=="C1")])
groups = list("C2"=scExp_cf$cell_id[which(scExp_cf$cell_cluster=="C2")])
myres = CompareWilcox(as.matrix(SingleCellExperiment::normcounts(scExp_cf)),
annot=as.data.frame(SingleCellExperiment::colData(scExp_cf)),
   ref_group=ref_group,groups=groups, featureTab=featureTab)

ChromSCape documentation built on Nov. 8, 2020, 6:57 p.m.