An implementation of a probabilistic modeling framework that jointly analyzes personal genome and transcriptome data to estimate the probability that a variant has regulatory impact in that individual. It is based on a generative model that assumes that genomic annotations, such as the location of a variant with respect to regulatory elements, determine the prior probability that variant is a functional regulatory variant, which is an unobserved variable. The functional regulatory variant status then influences whether nearby genes are likely to display outlier levels of gene expression in that person. See the RIVER website for more information, documentation and examples.
Package details 


Author  Yungil Kim [aut, cre], Alexis Battle [aut] 
Bioconductor views  Bayesian BiomedicalInformatics Clustering FunctionalGenomics FunctionalPrediction GeneExpression GeneRegulation GeneticVariability Genetics GenomicVariation Regression SNP SystemsBiology Transcription TranscriptomeVariant Transcriptomics 
Maintainer  Yungil Kim <[email protected]> 
License  GPL (>= 2) 
Version  1.4.0 
URL  https://github.com/ipw012/RIVER 
Package repository  View on Bioconductor 
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