cTRAP: Identification of candidate causal perturbations from differential gene expression data

Compare differential gene expression results with those from known cellular perturbations (such as gene knock-down, overexpression or small molecules) derived from the Connectivity Map. Such analyses allow not only to infer the molecular causes of the observed difference in gene expression but also to identify small molecules that could drive or revert specific transcriptomic alterations.

Package details

AuthorBernardo P. de Almeida [aut], Nuno Saraiva-Agostinho [aut, cre], Nuno L. Barbosa-Morais [aut, led]
Bioconductor views DifferentialExpression GeneExpression GeneSetEnrichment ImmunoOncology Pathways RNASeq Transcriptomics
MaintainerNuno Saraiva-Agostinho <nunodanielagostinho@gmail.com>
LicenseMIT + file LICENSE
URL https://nuno-agostinho.github.io/cTRAP https://github.com/nuno-agostinho/cTRAP
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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cTRAP documentation built on Nov. 8, 2020, 10:58 p.m.