Differential expression analysis of RNA-seq expression profiles with biological replication. Implements a range of statistical methodology based on the negative binomial distributions, including empirical Bayes estimation, exact tests, generalized linear models and quasi-likelihood tests. As well as RNA-seq, it be applied to differential signal analysis of other types of genomic data that produce counts, including ChIP-seq, Bisulfite-seq, SAGE and CAGE.
|Author||Yunshun Chen <[email protected]>, Aaron Lun <[email protected]>, Davis McCarthy <[email protected]>, Xiaobei Zhou <[email protected]>, Mark Robinson <[email protected]>, Gordon Smyth <[email protected]>|
|Bioconductor views||AlternativeSplicing BatchEffect Bayesian BiomedicalInformatics CellBiology ChIPSeq Clustering Coverage DNAMethylation DifferentialExpression DifferentialMethylation DifferentialSplicing Epigenetics FunctionalGenomics GeneExpression GeneSetEnrichment Genetics ImmunoOncology MultipleComparison Normalization Pathways QualityControl RNASeq Regression SAGE Sequencing SystemsBiology TimeCourse Transcription Transcriptomics|
|Maintainer||Yunshun Chen <[email protected]>, Aaron Lun <[email protected]>, Mark Robinson <[email protected]>, Davis McCarthy <[email protected]>, Gordon Smyth <[email protected]>|
|Package repository||View on Bioconductor|
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