scmod1.robust: Subtype Clustering Model using ESR1, ERBB2 and AURKA modules...

In genefu: Computation of Gene Expression-Based Signatures in Breast Cancer

Description

List of parameters defining the Subtype Clustering Model as published in Desmedt et al 2008.

Usage

data(scmod1.robust)

Format

List of parameters for SCMOD1:

parameters

List of parameters for the mixture of three Gaussians (ER-/HER2-, HER2+ and ER+/HER2-) that define the Subtype Clustering Model. The structure is the same than for an Mclust object.

cutoff.AURKA

Cutoff for AURKA module score in order to identify ER+/HER2- High Proliferation (aka Luminal B) tumors and ER+/HER2- Low Proliferation (aka Luminal A) tumors.

mod

ESR1, ERBB2 and AURKA modules.

Source

http://clincancerres.aacrjournals.org/content/14/16/5158.abstract?ck=nck

References

Desmedt C, Haibe-Kains B, Wirapati P, Buyse M, Larsimont D, Bontempi G, Delorenzi M, Piccart M, and Sotiriou C (2008) "Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes", Clinical Cancer Research, 14(16):5158–5165.

Examples

data(scmod1.robust)
str(scmod1.robust, max.level=1)

genefu documentation built on Jan. 28, 2021, 2:01 a.m.