scmgene.robust: Subtype Clustering Model using only ESR1, ERBB2 and AURKA...

In genefu: Computation of Gene Expression-Based Signatures in Breast Cancer

Description

List of parameters defining the Subtype Clustering Model as published in Wirapati et al 2009 and Desmedt et al 2008 but using single genes instead of gene modules.

Usage

data(scmgene.robust)

Format

List of parameters for SCMGENE:

parameters

List of parameters for the mixture of three Gaussians (ER-/HER2-, HER2+ and ER+/HER2-) that define the Subtype Clustering Model. The structure is the same than for an Mclust object.

cutoff.AURKA

Cutoff for AURKA module score in order to identify ER+/HER2- High Proliferation (aka Luminal B) tumors and ER+/HER2- Low Proliferation (aka Luminal A) tumors.

mod

ESR1, ERBB2 and AURKA modules.

Source

http://clincancerres.aacrjournals.org/content/14/16/5158.abstract?ck=nck

References

Desmedt C, Haibe-Kains B, Wirapati P, Buyse M, Larsimont D, Bontempi G, Delorenzi M, Piccart M, and Sotiriou C (2008) "Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes", Clinical Cancer Research, 14(16):5158–5165.

Examples

data(scmgene.robust)
str(scmgene.robust, max.level=1)

Example output

Loading required package: survcomp
Loading required package: survival
Loading required package: prodlim
Loading required package: mclust
Package 'mclust' version 5.3
Type 'citation("mclust")' for citing this R package in publications.
Loading required package: limma
Loading required package: biomaRt
Loading required package: iC10
Loading required package: pamr
Loading required package: cluster
Loading required package: iC10TrainingData
Loading required package: AIMS
Loading required package: e1071
Loading required package: Biobase
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following object is masked from 'package:limma':

    plotMA

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, cbind, colMeans, colSums, colnames, do.call,
    duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
    lapply, lengths, mapply, match, mget, order, paste, pmax, pmax.int,
    pmin, pmin.int, rank, rbind, rowMeans, rowSums, rownames, sapply,
    setdiff, sort, table, tapply, union, unique, unsplit, which,
    which.max, which.min

Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

List of 4
 $ parameters    :List of 3
 $ gaussian.AURKA: Named num [1:2] -0.28 0.294
  ..- attr(*, "names")= chr [1:2] "mean" "sigma"
 $ rescale.q     : num 0.05
 $ mod           :List of 3

genefu documentation built on Jan. 28, 2021, 2:01 a.m.