kersplatSimGeneMeans: Simulate Kersplat gene means
In splatter: Simple Simulation of Single-cell RNA Sequencing Data

Description Usage Arguments Details Value

Simulate Kersplat gene means

1	kersplatSimGeneMeans(params, verbose)

`params`	KersplatParams object containing simulation parameters.
`verbose`	logical. Whether to print progress messages

Gene means are simulated in one of two ways depending on the value of the mean.method parameter.

If mean.method is "fit" (default) then means are sampled from a Gamma distribution with shape equals mean.shape and rate equals mean.rate. Expression outliers are then added by replacing some values with the median multiplied by a factor from a log-normal distribution. This is the same process used for the Splat simulation.

If mean.method is "density" then means are sampled from the density object in the mean.density parameter using a rejection sampling method. This approach is more flexible but may violate some statistical assumptions.

KersplatParams object with gene means

splatter documentation built on Dec. 3, 2020, 2:01 a.m.