bmh: Block Partitioning

In hsphase: Phasing, Pedigree Reconstruction, Sire Imputation and Recombination Events Identification of Half-sib Families Using SNP Data

Description

Identifies the block structure (chromosome segments) in the half-sib family that each individual inherited from its sire.

Usage

bmh(GenotypeMatrix, forwardVectorSize = 30, excludeFP = TRUE, nsap = 3)

Arguments

GenotypeMatrix	matrix half-sib genotypes (one half-sib per row, with SNP ordered by mapping position in the columns. Data should be numeric. Use 0, 1 and 2 respectively for AA, AB and BB. Use 9 for missing data)
forwardVectorSize	integer number of heterozygous sites used to validate recombination events or check for genotyping errors (50k -> 30, 700k -> 120)
excludeFP	logical excludes SNPs that may cause heterozygous sites in the sire due to genotyping errors or map errors
nsap	integer number of SNP per block to validate recombinations (50k -> 3, 700k -> 10)

Value

Returns a matrix of the blocking structure that contains 1s, 2s and 0s. 1s and 2s are the two sire strands. The choice of strand is arbitrary for each chromosome and not consistent across chromosomes. 0s indicate regions of unknown origin.

Note

The genotype's matrix must contain individuals from only one half-sib family and one ordered chromosome.

See Also

ssp, phf, aio and imageplot

Examples

genotype <- matrix(c(
0,2,1,1,1,
2,0,1,2,2,
2,2,1,0,2,
2,2,1,1,1,
0,0,2,1,0), ncol = 5, byrow = TRUE) 

(result <- bmh(genotype))

hsphase documentation built on May 2, 2019, 3:44 p.m.