get_lit_css: Get literature Css

In httk: High-Throughput Toxicokinetics

Get literature Css

Description

This function retrieves a steady-state plasma concentration as a result of infusion dosing from the Wetmore et al. (2012) and (2013) publications and other literature.

Usage

get_lit_css(
  chem.cas = NULL,
  chem.name = NULL,
  daily.dose = 1,
  which.quantile = 0.95,
  species = "Human",
  clearance.assay.conc = NULL,
  output.units = "mg/L",
  suppress.messages = FALSE
)

Arguments

chem.cas	Either the cas number or the chemical name must be specified.
chem.name	Either the chemical name or the CAS number must be specified.
daily.dose	Total daily dose infused in units of mg/kg BW/day. Defaults to 1 mg/kg/day.
which.quantile	Which quantile from the SimCYP Monte Carlo simulation is requested. Can be a vector.
species	Species desired (either "Rat" or default "Human").
clearance.assay.conc	Concentration of chemical used in measureing intrinsic clearance data, 1 or 10 uM.
output.units	Returned units for function, defaults to mg/L but can also be uM (specify units = "uM").
suppress.messages	Whether or not the output message is suppressed.

Value

A numeric vector with the literature steady-state plasma concentration (1 mg/kg/day) for the requested quantiles

Author(s)

John Wambaugh

References

Wetmore, B.A., Wambaugh, J.F., Ferguson, S.S., Sochaski, M.A., Rotroff, D.M., Freeman, K., Clewell, H.J., Dix, D.H., Andersen, M.E., Houck, K.A., Allen, B., Judson, R.S., Sing, R., Kavlock, R.J., Richard, A.M., and Thomas, R.S., "Integration of Dosimetry, Exposure and High-Throughput Screening Data in Chemical Toxicity Assessment," Toxicological Sciences 125 157-174 (2012)

Wetmore, B.A., Wambaugh, J.F., Ferguson, S.S., Li, L., Clewell, H.J. III, Judson, R.S., Freeman, K., Bao, W, Sochaski, M.A., Chu T.-M., Black, M.B., Healy, E, Allen, B., Andersen M.E., Wolfinger, R.D., and Thomas R.S., "The Relative Impact of Incorporating Pharmacokinetics on Predicting in vivo Hazard and Mode-of-Action from High-Throughput in vitro Toxicity Assays" Toxicological Sciences, 132:327-346 (2013).

Wetmore, B. A., Wambaugh, J. F., Allen, B., Ferguson, S. S., Sochaski, M. A., Setzer, R. W., Houck, K. A., Strope, C. L., Cantwell, K., Judson, R. S., LeCluyse, E., Clewell, H.J. III, Thomas, R.S., and Andersen, M. E. (2015). "Incorporating High-Throughput Exposure Predictions with Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing" Toxicological Sciences, kfv171.

Examples

get_lit_css(chem.cas="34256-82-1")

get_lit_css(chem.cas="34256-82-1",species="Rat",which.quantile=0.5)

get_lit_css(chem.cas="80-05-7", daily.dose = 1,which.quantile = 0.5, output.units = "uM")

httk documentation built on Sept. 11, 2024, 9:32 p.m.