antibiotox: Toxicity of Seven Antibiotics on Photobacteria

In mixtox: Dose Response Curve Fitting and Mixture Toxicity Assessment

Toxicity of Seven Antibiotics on Photobacteria

Description

Seven antibiotics are: Neomycin sulfate(NEO), streptomycin sulfate(STR), kanamycin sulfate(KAN), spectinomycin dihydrochloridehydrate(SPE), paromomycin sulfate(PAR), dihydrostreptomycin sesquisulfate hydrate(DIH), and gentamycin sulfate(GEN). Their toxicity on photobacteria Q67 were tested using microplate toxicity analysis.
The concentration-responses include the toxicity of seven antibiotics, two eecr mixtures, and ten mixtures designed by udcr. The curve fitting information of seven antibiotics and a total of 12 mixtures.

Usage

data(antibiotox)

Format

A list with concentration-response data of 7 antibiotics, 12 mixtures, and associated fitting information.

PAR$x

a numeric vector of concentrations

PAR$y

a numeric matrix of responses

PAR$name

name of test substance

PAR$concNum

the number of concentrations

PAR$tierNum

the number of repetitions

PAR$type

type of test substance

sgl$model

models used to fit the concentration-response data

sgl$param

fitted coefficients of concentration-response curves

udcr.mix$model

models used to fit the concentration-response data of udcr mixtures on photobacteria

udcr.mix$param

fitted coefficients of concentration-response curves

udcr.pct

the percentage of individual chemicals in the udcr mixtures

eecr.mix$model

models used to fit the concentration-response data of eecr mixtures on photobacteria

eecr.mix$param

fitted coefficients of concentration-response curves

eecr.pct

the proportion of individual chemicals in the eecr mixtures

Details

Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:

E = \frac{{{I_0} - {I_i}}}{{{I_0}}}

where I_0 is the average of controls for inhibition tests or the average of the maximum effect for stimulation tests and I_i the average effect of the i^{th} treatment.

Examples

# example 1
## Retrive the toxicity information of PAR on photobacteria.
antibiotox$PAR
# example 2
## Retrive the toxicity information of two eecr mixtures on photobacteria.
antibiotox$eecr.mix

mixtox documentation built on June 20, 2022, 5:05 p.m.