antibiotox: Toxicity of Seven Antibiotics on Photobacteria

Description Usage Format Details Examples

Description

Seven antibiotics are: Neomycin sulfate(NEO), streptomycin sulfate(STR), kanamycin sulfate(KAN), spectinomycin dihydrochloridehydrate(SPE), paromomycin sulfate(PAR), dihydrostreptomycin sesquisulfate hydrate(DIH), and gentamycin sulfate(GEN). Their toxicity on photobacteria Q67 were tested using microplate toxicity analysis.
The concentration-responses include the toxicity of seven antibiotics, two eecr mixtures, and ten mixtures designed by udcr. The curve fitting information of seven antibiotics and a total of 12 mixtures.

Usage

1

Format

A list with concentration-response data of 7 antibiotics, 12 mixtures, and associated fitting information.

PAR$x

a numeric vector of concentrations

PAR$y

a numeric matrix of responses

PAR$name

name of test substance

PAR$concNum

the number of concentrations

PAR$tierNum

the number of repetitions

PAR$type

type of test substance

sgl$model

models used to fit the concentration-response data

sgl$param

fitted coefficients of concentration-response curves

udcr.mix$model

models used to fit the concentration-response data of udcr mixtures on photobacteria

udcr.mix$param

fitted coefficients of concentration-response curves

udcr.pct

the percentage of individual chemicals in the udcr mixtures

eecr.mix$model

models used to fit the concentration-response data of eecr mixtures on photobacteria

eecr.mix$param

fitted coefficients of concentration-response curves

eecr.pct

the proportion of individual chemicals in the eecr mixtures

Details

Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:

E = \frac{{{I_0} - {I_i}}}{{{I_0}}}

where I_0 is the average of controls for inhibition tests or the average of the maximum effect for stimulation tests and I_i the average effect of the i^{th} treatment.

Examples

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# example 1
## Retrive the toxicity information of PAR on photobacteria.
antibiotox$PAR
# example 2
## Retrive the toxicity information of two eecr mixtures on photobacteria.
antibiotox$eecr.mix

Example output

$x
 [1] 1.718e-07 2.291e-07 3.551e-07 5.269e-07 7.789e-07 1.145e-06 1.718e-06
 [8] 2.291e-06 3.551e-06 5.269e-06 7.789e-06 1.145e-05

$y
         tier1        tier2      tier3
3  -0.01907293 -0.023076476 0.02782089
4  -0.01770792  0.009446548 0.06065272
5   0.02687944  0.063064935 0.07175286
6   0.04713938  0.086031958 0.10548726
7   0.13895028  0.141419024 0.14888114
8   0.19878043  0.204747952 0.19074755
9   0.30712384  0.315195821 0.36082551
10  0.49816509  0.467559601 0.51365877
11  0.74254537  0.731641939 0.75497213
12  0.89264161  0.882151175 0.88362630
13  0.91703287  0.915215125 0.91532119
14  0.93887304  0.929476159 0.93460542

$name
[1] "PAR"

$concNum
[1] 12

$tierNum
[1] 3

$type
[1] "antibiotox"

$model
[1] "Weibull" "Weibull"

$param
     alpha beta gamma
ee05 14.36 2.53     0
ee50 14.92 2.65     0

mixtox documentation built on May 1, 2019, 8:41 p.m.

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