ecaPred: Mixture Effect Predicted by CA at Particular Concentration of...

In mixtox: Dose Response Curve Fitting and Mixture Toxicity Assessment

Mixture Effect Predicted by CA at Particular Concentration of a Mixture

Description

According to the fitted concentration-response information of mixtures. The concentration (e.g., ECx) that causes certain effect in the mixture will be calculated. ecaPred will predict how much effect will be caused at ECx according to concentration addition. The individual concentration-responses should be fitted only based on the following six models: Hill, Weibull, Logit, BCW, BCL, and GL.

Usage

ecaPred(effv, sgl, mix, pctMix, sav = FALSE)

Arguments

effv	numeric vector with single or multiple effect values (0 ~ 1).
sgl	A list with sgl$model and sgl$param. sgl$model is character vector of equations used to fit the concentration-response data of individual chemicals: Hill, Weibull, Logit, BCW, BCL, GL. sgl$param is numeric matrix of fitting coefficients with rownames (equations) and colnames (Alpha, Beta, and Gamma). For equations with only two parameters, Gamma can be set as zero or any other numeric value.
mix	A list with mix$model and mix$param. mix$model is character vector of equations used to fit the concentration-response data of mixtures: Hill, Weibull, Logit, BCW, BCL, GL. mix$param is numeric matrix of fitting coefficients of mixtures' concentration-response data with rownames (selected equations) and colnames (Alpha, Beta, and Gamma). For equations with only two parameters, Gamma can be set as zero or any other numeric value.
pctMix	A numeric matrix, the concentration ratio (percent) of every component in the mixture.
sav	TRUE: save output to a default file; FALSE: output will not be saved; a custom file directory: save output to the custom file directory.

Details

ecaPred calculate the effect concentrations based on the fitted concentration-response information of the mixture according to the input effects effv (e.g., 0.05 and 0.5). The concentration of individual component c_i is computed based on mixture's ECx and the proportion of component in the mixture p_i. Then the CA effect will be calculated based on the concentration addition.

Value

A numeric matrix of predicted effects

See Also

eiaPred

Examples

## example
# predict the CA predicted response at the concentrations that cause 5%, 10%, 20%, and 50% 
# effect of antibiotic mixtures
# each mixture contains eight components. Totally, there are 10 mixtures designed by the udcr.

sgl <- antibiotox$sgl
mix <- antibiotox$udcr.mix
pct <- antibiotox$udcr.pct
ecaPred(effv = c(0.05, 0.1, 0.20, 0.5), sgl, mix, pct)

mixtox documentation built on June 20, 2022, 5:05 p.m.