mixtox: Dose-Response Curve Fitting and Mixture Toxicity Assessment

In mixtox: Dose Response Curve Fitting and Mixture Toxicity Assessment

Dose-Response Curve Fitting and Mixture Toxicity Assessment

Description

Curve Fitting for monotonic(sigmoidal) & non-monotonic(J-shaped) concentration-response data. Prediction of mixture toxicity based on reference models such as 'concentration addition', 'independent action', and 'generalized concentration addition'.

Details

Package:	mixtox
Type:	Package
Version:	1.3.3
Date:	2022-06-19
License:	GPL-2

(1) Curve fitting of concentration-responses based on 13 monotonic(sigmoidal) and 4 non-monotonic(J-shaped) models, goodness of fit, and calculation of confidence interval .
(2) Experimental design for mixture toxicity. acr: arbitrary concentration ratio; eecr: equal effect concentration ratio; udcr: uniform design concentration ratio.
(3) Mixture toxicity prediction based on reference models such as concentration addition (CA), independent action (IA), and generalized concentration addition (GCA).

Author(s)

xiangwei zhu
Maintainer: xiangwei zhu <[e-mail]>

References

Zhu, X.-W., Chen, J.-Y. (2016). mixtox: An R Package for Mixture Toxicity Assessment. R Journal, 8(2), 422-434.
Zhu, X.-W., Ge, H.-L., Cao, Y.-B. (2016). Mixture cytotoxicity assessment of ionic liquids and heavy metals in MCF-7 cells using mixtox. Chemosphere, 163, 544-551.
Zhu X-W, Liu S-S, Qin L-T, Chen F, Liu H-L. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicology and Environmental Safety 89:130-136.
Dunnett, C. W. 1964. New Tables for Multiple Comparisons with a Control. Biometrics 30(3):482-491.
Hickernell, Fred J. 1996. A Generalized Discrepancy and Quadrature Error Bound. Mathematics of Computation 67(211):299-322.
Howard, Gregory J., Jennifer J. Schlezinger, Mark E. Hahn, and Thomas F. Webster. 2010. Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists. Environmental Health Perspectives 118(5):666-672.
Scholze, M. et al. 2001. A General Best-Fit Method for Concentration-Response Curves and the Estimation of Low-Effect Concentrations. Environmental Toxicology and Chemistry 20(2):448-457.
Wang, Yuan and Kai-Tai Fang. 1996. Uniform Design of Experiments with Mixtures. Science in China Series A-Mathematics Physics Astronomy 39(3):264-275.
Backhaus, T., Faust, M., 2012. Predictive environmental risk assessment of chemical mixtures: A conceptual framework. Environmental Science and Technology. 46, 2564-2573.

mixtox documentation built on June 20, 2022, 5:05 p.m.