cytotox: Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7

Description Usage Format Details Source Examples

Description

Chemicals include four heavy metal ions: {\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}(Ni), {\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}} (Zn), {\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}} (Cu), and {\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}} (Mn); four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim), 1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate (Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
The concentration-response data include the cytotoxicity of eight compounds, two mixtures designed by eecr, and ten mixtures designed by udcr.
The fitting information of eight chemicals and a total of 12 mixtures.

Usage

1

Format

A list with concentration-response data of 8 chemicals, 2 eecr mixtures, 10 udcr mixtures, and associated fitting information.

Ni$x

a numeric vector of test concentrations

Ni$y

a numeric matrix of responses

Ni$name

test substances

Ni$concNum

the number of test concentrations

Ni$tierNum

the number of repetitions

Ni$type

type of test substance: single chemicals or mixtures

sgl$model

models used to fit the concentration-response data of individual chemicals

sgl$param

fitted coefficients of concentration-response curves

udcr.mix$model

models used to fit the concentration-response data of udcr mixtures

udcr.mix$param

fitted coefficients of the concentration-response curves corresponding to udcr.mix$model

$udcr.pct

the proportion of individual chemicals in udcr mixtures

Details

Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:

E = \frac{{{I_0} - {I_i}}}{{{I_0}}}

where I_0 is the average of controls for inhibition tests or the average of the maximum effect for stimulation tests and I_i the average effect of the i^{th} treatment.

Source

The cytotoxicity experiments were conducted in our lab

Examples

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# example 1
## Retrive the toxicity data of Ni on MCF-7.
cytotox$Ni

# example 2
## Retrive the toxicity information of ten udcr mixtures on MCF-7.
cytotox$udcr.mix

Example output

$x
 [1] 3.07119e-06 4.29966e-06 6.55186e-06 9.41830e-06 1.39227e-05 2.04746e-05
 [7] 3.07119e-05 4.29966e-05 6.55186e-05 9.41830e-05 1.39227e-04 2.04746e-04

$y
        tier1       tier2      tier3
3  0.01347381 -0.06216216 0.02149674
4  0.01772870  0.09407484 0.06187845
5  0.10556175  0.09968815 0.13058764
6  0.15814001  0.14708940 0.17157207
7  0.25326715  0.23191268 0.16584631
8  0.34596292  0.38690229 0.35148167
9  0.36480600  0.43617464 0.45966851
10 0.51433492  0.54875260 0.53952788
11 0.65444231  0.65166320 0.67152185
12 0.72252051  0.70810811 0.72636866
13 0.72586364  0.74896050 0.76102461
14 0.75048121  0.76268191 0.76976394

$name
[1] "ni"

$concNum
[1] 12

$tierNum
[1] 3

$type
[1] "type"

$model
 [1] "Hill"    "BCL"     "Weibull" "Hill"    "BCW"     "Weibull" "Hill"   
 [8] "Logit"   "Logit"   "BCW"    

$param
    Alpha     Beta Gamma
U1  56.79  0.19600  0.00
U2  55.92 23.60000  0.39
U3   7.54  2.78000  0.00
U4   2.33  0.00541  0.00
U5  18.43  4.03000  0.14
U6   6.02  2.35000  0.00
U7   1.63  0.00174  0.00
U8  10.01  3.18000  0.00
U9  14.24  4.83000  0.00
U10 24.02  6.08000  0.18

mixtox documentation built on May 1, 2019, 8:41 p.m.

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