cytotox | R Documentation |

Chemicals include four heavy metal ions:
*{\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}*(Ni),
*{\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}}* (Zn),
*{\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}}* (Cu), and
*{\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}}* (Mn);
four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim),
1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate
(Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).

The concentration-response data include the cytotoxicity of eight compounds,
two mixtures designed by eecr, and ten mixtures designed by udcr.

The fitting information of eight chemicals and a total of 12 mixtures.

data(cytotox)

A list with concentration-response data of 8 chemicals, 2 eecr mixtures, 10 udcr mixtures, and associated fitting information.

`Ni$x`

a numeric vector of test concentrations

`Ni$y`

a numeric matrix of responses

`Ni$name`

test substances

`Ni$concNum`

the number of test concentrations

`Ni$tierNum`

the number of repetitions

`Ni$type`

type of test substance: single chemicals or mixtures

`sgl$model`

models used to fit the concentration-response data of individual chemicals

`sgl$param`

fitted coefficients of concentration-response curves

`udcr.mix$model`

models used to fit the concentration-response data of udcr mixtures

`udcr.mix$param`

fitted coefficients of the concentration-response curves corresponding to udcr.mix$model

`$udcr.pct`

the proportion of individual chemicals in udcr mixtures

Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones:

*E = \frac{{{I_0} - {I_i}}}{{{I_0}}}*

where *I_0* is the average of controls for inhibition tests or the average
of the maximum effect for stimulation tests and *I_i* the average
effect of the *i^{th}* treatment.

The cytotoxicity experiments were conducted in our lab

# example 1 ## Retrive the toxicity data of Ni on MCF-7. cytotox$Ni # example 2 ## Retrive the toxicity information of ten udcr mixtures on MCF-7. cytotox$udcr.mix

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