hormesis | R Documentation |

Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and
1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
Two organic solvents: Acetonitrile(ACN) and acetone.

The concentration-response data include the effect of these four compounds
on firefly luciferase.
Those concentration-responses were fitted using non-monotonic models.

data(hormesis)

A list with non-monotonic concentration-responses of four chemicals and associated fitting information.

`OmimCl$x`

a numeric vector of concentrations

`OmimCl$y`

a numeric matrix of responses

`OmimCl$name`

name of test substance

`OmimCl$concNum`

the number of concentrations

`OmimCl$tierNum`

the number of repetitions

`OmimCl$type`

type of test substance

`sgl$model`

model used to fit the concentration-response data

`sgl$param`

fitted coefficients of those curves corresponding to sgl$model

`sgl$minx`

numeric vector with multiple concentrations that induce maximun stimulation

`sgl$miny`

the largest stimulation

The non-monotonic concentration-responses need to be scaled into [0, 1] using the following equation:

*E = \frac{{{I_0} - {I_i}}}{{{I_0}}}*

where *I_0* is the average of controls for inhibition test or the average
of the maximum effect for the stimulation test and *I_i* the average
effect of the *i^{th}* treatment.

Eexperiments were conducted in our lab. Detailed descripttion can be found in references

Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.

#example 1 ## Retrive the toxicity data of acetonitrile on firefly luciferase. hormesis$ACN #example 2 ## Retrive the minx of OmimCl, HmimCl, ACN, and Acetone hormesis$sgl$minx

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