hormesis: Non-monotonic Concentration-response Data

In mixtox: Dose Response Curve Fitting and Mixture Toxicity Assessment

Non-monotonic Concentration-response Data

Description

Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim). Two organic solvents: Acetonitrile(ACN) and acetone.
The concentration-response data include the effect of these four compounds on firefly luciferase. Those concentration-responses were fitted using non-monotonic models.

Usage

data(hormesis)

Format

A list with non-monotonic concentration-responses of four chemicals and associated fitting information.

OmimCl$x

a numeric vector of concentrations

OmimCl$y

a numeric matrix of responses

OmimCl$name

name of test substance

OmimCl$concNum

the number of concentrations

OmimCl$tierNum

the number of repetitions

OmimCl$type

type of test substance

sgl$model

model used to fit the concentration-response data

sgl$param

fitted coefficients of those curves corresponding to sgl$model

sgl$minx

numeric vector with multiple concentrations that induce maximun stimulation

sgl$miny

the largest stimulation

Details

The non-monotonic concentration-responses need to be scaled into [0, 1] using the following equation:

E = \frac{{{I_0} - {I_i}}}{{{I_0}}}

where I_0 is the average of controls for inhibition test or the average of the maximum effect for the stimulation test and I_i the average effect of the i^{th} treatment.

Source

Eexperiments were conducted in our lab. Detailed descripttion can be found in references

References

Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.

Examples

#example 1
## Retrive the toxicity data of acetonitrile on firefly luciferase.
hormesis$ACN

#example 2
## Retrive the minx of OmimCl, HmimCl, ACN, and Acetone
hormesis$sgl$minx

mixtox documentation built on June 20, 2022, 5:05 p.m.