Description Usage Arguments Value Author(s) References Examples
Uses the GeneRank to calculate the ranks for genes. Afterwards the ranks are transformed as needed for the RRFE algorithm.
1 2 | getGeneRanks(x, y, mapping, Gsub, method = "foldChange",
d = 0.5)
|
x |
a p x n matrix of expression measurements with p samples and n genes. |
y |
a factor of length p comprising the class labels. |
mapping |
a mapping that defines how probe sets are summarized to genes. |
Gsub |
an adjacency matrix that represents the underlying biological network. |
method |
see help of summarizeProbes |
d |
the damping factor which controls the influence of the network data and the fold change on the ranking of the genes. Defaults to 0.5 |
a ranking of the genes for which pathway knowledge was available.
Marc Johannes JohannesMarc@gmail.com
Johannes M, et al. (2010). Integration Of Pathway Knowledge Into A Reweighted Recursive Feature Elimination Approach For Risk Stratification Of Cancer Patients. Bioinformatics
1 2 3 4 5 6 | ## Not run:
library(pathClass)
data(example_data)
ranks = getGeneRanks(x, y, mapping=mapping, Gsub=adjacency.matrix)
## End(Not run)
|
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