LineagePulse is a differential expression and expression model fitting package tailored to single-cell RNA-seq data (scRNA-seq). LineagePulse accounts for batch effects, drop-out and variable sequencing depth. One can use LineagePulse to perform longitudinal differential expression analysis across pseudotime as a continuous coordinate or between discrete groups of cells (e.g. pre-defined clusters or experimental conditions). Expression model fits can be directly extracted from LineagePulse.
|Bioconductor views||CellBasedAssays CellBiology DifferentialExpression GeneExpression Sequencing SingleCell Software StatisticalMethod TimeCourse|
|Package repository||View on GitHub|
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