evalSigGeneImportance: Calculate gene-signature importance

In YosefLab/VISION: Functional interpretation of single cell RNA-seq latent manifolds

Calculate gene-signature importance

Description

For each signature, the contribution of each gene to the signature score is evaluated by calculating the covariance between signature scores and expression The correlation of genes with a negative sign in the signature are inverted.

Usage

evalSigGeneImportance(sigScores, sigData, normExpr)

Arguments

sigScores	matrix of signature scores (Cells x Signatures)
sigData	list of Signature objects
normExpr	output from calling getNormalizedCopySparse

Value

named list with one item per signature. Values are named vectors of each gene's association (covariance) with the signature.

YosefLab/VISION documentation built on Feb. 19, 2023, 9:50 p.m.