nulldistrib: Weighted beta/binomial distribution

In anthony-aylward/chenimbalance: Allelic imbalance mapping procedure from Chen et al. A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals (2016)

Description

Weighted beta/binomial distribution

Usage

nulldistrib(w, minN = 6, p = 0.5, binSize = 40,
  distrib = "binomial", b = 0)

Arguments

w	Data frame or matrix giving
minN	Minimum coverage (min total num of reads (since it's left open right closed))
p	Binomial parameter (null probability)

Details

d.combined collects all results and correspond it to an allelic ratio: col1=allelicRatio (based on binomial n=6, ar=0,1/6,2/6...) col2=corresponding weighted value in binomial distribution, i.e. pdf(n, k, p) * (num of empirical SNPs at n counts)

Value

The weighted null beta/binomial probability mass function

anthony-aylward/chenimbalance documentation built on May 17, 2019, 12:50 p.m.