AVANA_Library: Genome-wide annotation for the AVANA sgRNA library

In francescojm/CRISPRcleanR: Unsupervised correction of gene independent cell responses to CRISPR-cas9 targeting

Genome-wide annotation for the AVANA sgRNA library

Description

A data frame with a named row for each sgRNA of the AVANA sgRNA library [1] including annotations such as targeted genes, and genomic coordinates.

Usage

data(AVANA_Library)

Format

A a row named data frame with 71482 observations (one for each sgRNA) of the following 7 variables.

CODE

alphanumerical identifier of the sgRNAs;

GENES

targeted gene;

EXONE

exone of the targeted genomic region (string with 'ex' prefix followed by the exone number);

CHRM

chromosome of where the targeted region resides (string)

STRAND

targeted DNA strand ('+' or '-')

STARTpos

starting genomic coordinate of the targeted genomic region (numeric);

ENDpos

ending genomic coordinate of the targeted genomic region (numeric).

seq

nucelotidic sequence of the sgRNAs without the PAM. (string).

References

[1] Meyers RM, Bryan JG, McFarland JM, Weir BA. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature. 2017.

Examples

data(AVANA_Library)
head(AVANA_Library)

francescojm/CRISPRcleanR documentation built on April 30, 2023, 5:41 a.m.