Identification of aberrant gene expression in RNA-seq data. Read count expectations are modeled by an autoencoder to control for confounders in the data. Given these expectations, the RNA-seq read counts are assumed to follow a negative binomial distribution with a gene-specific dispersion. Outliers are then identified as read counts that significantly deviate from this distribution. Furthermore, OUTRIDER provides useful plotting functions to analyze and visualize the results.
Package details |
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Bioconductor views | Alignment GeneExpression Genetics ImmunoOncology RNASeq Sequencing Transcriptomics |
Maintainer | |
License | MIT + file LICENSE |
Version | 1.20.1 |
URL | https://github.com/gagneurlab/OUTRIDER |
Package repository | View on GitHub |
Installation |
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