This package combines Mendelian randomisation (MR) and colocalisation (coloc) with the aim of providing causal evidence between exposure-outcome pairs. The pipeline favours molecular data as exposure, for example, gene expression or protein abundance quantitative trait loci (QTLs), but can be used for non-molecular exposures as well. The pipeline will also annotate and combine results with drug target-related evidence from the literature, and has functionality to output shareable reports between investigators.
Within R, the package can be installed for this GitHub like so:
remotes::install_github("https://github.com/jwr-git/mrpipeline")
See here: coming soon
A docker image will also be available soon.
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