do_mr: Run Mendelian randomisation analyses

In jwr-git/mrpipeline: Implements a Ready-for-Use Mendelian Randomisation Pipeline

Run Mendelian randomisation analyses

Description

Runs Mendelian randomisation and related analyses:

1. Wald ratio, see .wr_taylor_approx()

2. Inverse variance weighted, see .ivw.delta()

3. Steiger filtering, see TwoSampleMR::directionality_test()

Usage

do_mr(dat, f_cutoff = 10, all_wr = TRUE, verbose = TRUE)

Arguments

dat	A data.frame of harmonised data
f_cutoff	Define an F-statistic cutoff (Optional)
all_wr	Should the Wald ratio be calculated for all SNPs, even if IVW can be used? (Optional)
verbose	Display verbose information (Optional, boolean)

Value

A data.frame of MR results

See Also

[.wr_taylor_approx()], [.ivw_delta()], [TwoSampleMR::directionality_test()]

jwr-git/mrpipeline documentation built on Oct. 2, 2022, 3:41 p.m.