README.md
In lutsik/MeDeCom: Decomposition of heterogeneous methylomes
MeDeCom
MeDeCom is an R package for reference-free decomposition of heterogeneous DNA methylation profiles.
It uses constrained matrix factorization enhanced by biologically-relevant constraints and a specially tailored regularization.
See MeDeCom vignette for a more detailed description and an example analysis.
Publications
MeDeCom has originially been published in Genome Biology. Together with its accompanying packages DecompPipeline and FactorViz, MeDeCom is part of a published protocol for reference-free deconvolution of complex DNA methylation data (see also http://epigenomics.dkfz.de/DecompProtocol/).
lutsik/MeDeCom documentation built on Feb. 15, 2023, 11:32 a.m.
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MeDeCom
MeDeCom is an R package for reference-free decomposition of heterogeneous DNA methylation profiles. It uses constrained matrix factorization enhanced by biologically-relevant constraints and a specially tailored regularization. See MeDeCom vignette for a more detailed description and an example analysis.
Publications
MeDeCom has originially been published in Genome Biology. Together with its accompanying packages DecompPipeline and FactorViz, MeDeCom is part of a published protocol for reference-free deconvolution of complex DNA methylation data (see also http://epigenomics.dkfz.de/DecompProtocol/).
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We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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